Zoladex versus orchiectomy in treatmentof advanced prostate cancer: a randomized trial

Mark S. Soloway, Joseph A. Smith, Gerald Chodak, Mark Scott, Nicholas J. Vogelzang, Gerald Kennealey, Norman L. Block, Timothy C. Gau, Paul F. Schellhammer

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

We report preliminary results for the first 164 patients enrolled in a multicenter studycomparing the endocrine effects, efficacy, and safety of 3.6 mg of goserelin acetate (Zoladex) and orchiectomy in patients with Stage D2 prostate cancer. Eighty-one patients were randomly allocated to receive Zoladex and 83 to orchiectomy. The median follow-up time for all patients was two hundred ten days. Median serum levels of testosterone were reduced to castrate levels (< 50 ng/dL) within four weeks in both groups and remained suppressed for up to sixty weeks. An objective response according to modified criteria of the National Prostatic Cancer Project was observed in 81 percent and 78 percent of patients in the Zoladex and orchiectomy groups, respectively. There were no statistically significant differences between treatment groups in the distributions of time to treatment failure or time to disease progression. The most commonly reported adverse events in both treatment groups were hot flashes, cancer-related pain, unspecified pain, and urinary symptoms. These results suggest that Zoladex may offer an alternative to orchiectomy in the treatment of advanced prostate cancer.

Original languageEnglish (US)
Pages (from-to)46-51
Number of pages6
JournalUrology
Volume37
Issue number1
DOIs
StatePublished - Jan 1991

ASJC Scopus subject areas

  • Urology

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    Soloway, M. S., Smith, J. A., Chodak, G., Scott, M., Vogelzang, N. J., Kennealey, G., Block, N. L., Gau, T. C., & Schellhammer, P. F. (1991). Zoladex versus orchiectomy in treatmentof advanced prostate cancer: a randomized trial. Urology, 37(1), 46-51. https://doi.org/10.1016/0090-4295(91)80077-K