Young capillary vessels rejuvenate aged pancreatic islets

Joana Almaça, Judith Molina, Rafael Arrojoe Drigo, Midhat H. Abdulreda, Won Bae Jeon, Per Olof Berggren, Alejandro Caicedo, Hong Gil Nam

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucose sensing and the insulin secretory capacity of islet beta cells. Accordingly, when transplanted into the anterior chamber of the eye of young mice with diabetes, islets from old mice are revascularized with healthy blood vessels, show strong islet cell proliferation, and fully restore control of glycemia. Our results indicate that beta cell function does not decline with age and suggest that islet function is threatened by an age-dependent impairment of islet vascular function. Strategies to mitigate age-dependent dysregulation in glycemia should therefore target systemic and/or local inflammation and fibrosis of the aged islet vasculature.

Original languageEnglish (US)
Pages (from-to)17612-17617
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume111
Issue number49
DOIs
StatePublished - Dec 9 2014

    Fingerprint

Keywords

  • Aging
  • Glucose metabolism
  • Insulin secretion
  • Pancreatic islets
  • Vasculature

ASJC Scopus subject areas

  • General

Cite this