Yersinia pestis YscG protein is a Syc-like chaperone that directly binds YscE

J. B. Day, I. Guller, G. V. Plano

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Pathogenic Yersinia species secrete virulence proteins, termed Yersinia outer proteins (Yops), upon contact with a eukaryotic cell. The secretion machinery is composed of 21 Yersinia secretion (Ysc) proteins. Yersinia pestis mutants defective in expression of YscG or YscE were unable to export the Yops. YscG showed structural and limited amino-acid-sequence similarities to members of the specific Yop chaperone (Syc) family of proteins. YscG specifically recognized and bound YscE; however, unlike previously characterized Syc substrates, YscE was not exported from the cell. These data suggest that YscG functions as a chaperone for YscE.

Original languageEnglish (US)
Pages (from-to)6466-6471
Number of pages6
JournalInfection and immunity
Volume68
Issue number11
DOIs
StatePublished - 2000

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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