Yersinia pestis interacts with SIGNR1 (CD209b) for promoting host dissemination and infection

Kun Yang, Yingxia He, Chae Gyu Park, Young Sun Kang, Pei Zhang, Yanping Han, Yujun Cui, Silvia Bulgheresi, Andrey P. Anisimov, Svetlana V. Dentovskaya, Xiaoling Ying, Lingyu Jiang, Honghui Ding, Olivia Adhiambo Njiri, Shusheng Zhang, Guoxing Zheng, Lianxu Xia, Biao Kan, Xin Wang, Huaiqi JingMeiying Yan, Wei Li, Yuanzhi Wang, Xiding Xiamu, Gang Chen, Ding Ma, Sara Schesser Bartra, Gregory V. Plano, John D. Klena, Ruifu Yang, Mikael Skurnik, Tie Chen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Yersinia pestis, a Gram-negative bacterium and the etiologic agent of plague, has evolved from Yersinia pseudotuberculosis, a cause of a mild enteric disease. However, the molecular and biological mechanisms of how Y. pseudotuberculosis evolved to such a remarkably virulent pathogen, Y. pestis, are not clear. The ability to initiate a rapid bacterial dissemination is a characteristic hallmark of Y. pestis infection. A distinguishing characteristic between the two Yersinia species is that Y. pseudotuberculosis strains possess an O-antigen of lipopolysaccharide (LPS) while Y. pestis has lost the O-antigen during evolution and therefore exposes its core LPS. In this study, we showed that Y. pestis utilizes its core LPS to interact with SIGNR1 (CD209b), a C-type lectin receptor on antigen presenting cells (APCs), leading to bacterial dissemination to lymph nodes, spleen and liver, and the initiation of a systemic infection. We therefore propose that the loss of O-antigen represents a critical step in the evolution of Y. pseudotuberculosis into Y. pestis in terms of hijacking APCs, promoting bacterial dissemination and causing the plague.

Original languageEnglish (US)
Article number96
JournalFrontiers in immunology
Volume10
Issue numberMAR
DOIs
StatePublished - 2019

Keywords

  • Antigen presenting cells (APCs)
  • Bacterial dissemination
  • Core lipopolysaccharide/lipooligosaccharides (core LPS/LOS)
  • Dendritic cells (DCs)
  • Host-pathogen interactions
  • Macrophages
  • SIGNR1 (CD209b)
  • Yersinia pestis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Yang, K., He, Y., Park, C. G., Kang, Y. S., Zhang, P., Han, Y., Cui, Y., Bulgheresi, S., Anisimov, A. P., Dentovskaya, S. V., Ying, X., Jiang, L., Ding, H., Njiri, O. A., Zhang, S., Zheng, G., Xia, L., Kan, B., Wang, X., ... Chen, T. (2019). Yersinia pestis interacts with SIGNR1 (CD209b) for promoting host dissemination and infection. Frontiers in immunology, 10(MAR), [96]. https://doi.org/10.3389/fimmu.2019.00096