XLong noncoding RNAs usher in a new era in the biology of enhancers

Ulf Andersson Orom; Ramin Shiekhattar

doi:10.1016/j.cell.2013.08.028

XLong noncoding RNAs usher in a new era in the biology of enhancers

Ulf Andersson Orom, Ramin Shiekhattar

Research output: Contribution to journal › Review article › peer-review

204 Scopus citations

Abstract

Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.

Original language	English (US)
Pages (from-to)	1190
Number of pages	1
Journal	Cell
Volume	154
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2013.08.028
State	Published - Sep 12 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2013.08.028

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title = "XLong noncoding RNAs usher in a new era in the biology of enhancers",

abstract = "Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.",

author = "Orom, {Ulf Andersson} and Ramin Shiekhattar",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is supported by the Alexander von Humboldt Foundation Sofja Kovalevskaja Award to U.A.{\O}. and NIH grant GM078455 to R.S.",

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AU - Orom, Ulf Andersson

AU - Shiekhattar, Ramin

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Y1 - 2013/9/12

N2 - Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.

AB - Enhancer-associated long noncoding RNAs act over long distances and across chromosomes to activate transcription at distal promoters. Here, we address the latest advances made toward understanding the role of long noncoding RNA expression and the involvement of these RNAs in enhancer function through association with protein factors and modulation of chromatin structure.

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XLong noncoding RNAs usher in a new era in the biology of enhancers

Abstract

ASJC Scopus subject areas

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