Abstract
Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.
| Original language | English |
|---|---|
| Journal | Cell |
| Volume | 153 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 6 2013 |
Fingerprint
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
XDynamics of hippocampal neurogenesis in adult humans. / Spalding, Kirsty L.; Bergmann, Olaf; Alkass, Kanar; Bernard, Samuel; Salehpour, Mehran; Huttner, Hagen B.; Boström, Emil; Westerlund, Isabelle; Vial, Céline; Buchholz, Bruce A.; Possnert, Göran; Mash, Deborah C; Druid, Henrik; Frisén, Jonas.
In: Cell, Vol. 153, No. 6, 06.06.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - XDynamics of hippocampal neurogenesis in adult humans
AU - Spalding, Kirsty L.
AU - Bergmann, Olaf
AU - Alkass, Kanar
AU - Bernard, Samuel
AU - Salehpour, Mehran
AU - Huttner, Hagen B.
AU - Boström, Emil
AU - Westerlund, Isabelle
AU - Vial, Céline
AU - Buchholz, Bruce A.
AU - Possnert, Göran
AU - Mash, Deborah C
AU - Druid, Henrik
AU - Frisén, Jonas
PY - 2013/6/6
Y1 - 2013/6/6
N2 - Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.
AB - Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.
UR - http://www.scopus.com/inward/record.url?scp=84878831768&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878831768&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2013.05.002
DO - 10.1016/j.cell.2013.05.002
M3 - Article
C2 - 23746839
AN - SCOPUS:84878831768
VL - 153
JO - Cell
JF - Cell
SN - 0092-8674
IS - 6
ER -