@article{35381836d31649cdb613d0c9b33c6de3,
title = "XDynamics of hippocampal neurogenesis in adult humans",
abstract = "Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.",
author = "Spalding, {Kirsty L.} and Olaf Bergmann and Kanar Alkass and Samuel Bernard and Mehran Salehpour and Huttner, {Hagen B.} and Emil Bostr{\"o}m and Isabelle Westerlund and C{\'e}line Vial and Buchholz, {Bruce A.} and G{\"o}ran Possnert and Mash, {Deborah C.} and Henrik Druid and Jonas Fris{\'e}n",
note = "Funding Information: We thank M. Toro, S. Giatrellis, A. Busch, E. Kiss, and H. Ismail for flow cytometry; K. H{\aa}kansson for AMS sample preparation; A. R{\'a}cz for tissue procurement; and F. Gage, G. Kempermann, and L. Slomianka for valuable discussions. The staff at the Swedish National Board of Forensic Medicine is acknowledged for cooperation in tissue donation. This study was supported by the Swedish Research Council, T. Stiftelsen, Hj{\"a}rnfonden, the Swedish Foundation for Strategic Research, the National Alliance for Research on Schizophrenia and Depression, AFA F{\"o}rs{\"a}kringar, the Knut and Alice Wallenberg Foundation, the National Institute on Drug Abuse (DA031429), the European Research Council, the National Institutes of Health (NIH) and the National Center for Research Resources (5P41RR013461), the NIH and the National Institute of General Medical Sciences (8P41GM103483), and the regional agreement on medical training and clinical research between Stockholm County Council and the Karolinska Institute (ALF 20080508). This work was performed, in part, with the support of the U.S. Department of Energy by the Lawrence Livermore National Laboratory (under contract DE-AC52-07NA27344). H.B.H. was funded by a grant from the German Research Foundation (DFG: Hu 1961/1-1). ",
year = "2013",
month = jun,
day = "6",
doi = "10.1016/j.cell.2013.05.002",
language = "English (US)",
volume = "153",
pages = "1219",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",
}