XDynamics of hippocampal neurogenesis in adult humans

Kirsty L. Spalding; Olaf Bergmann; Kanar Alkass; Samuel Bernard; Mehran Salehpour; Hagen B. Huttner; Emil Boström; Isabelle Westerlund; Céline Vial; Bruce A. Buchholz; Göran Possnert; Deborah C. Mash; Henrik Druid; Jonas Frisén

doi:10.1016/j.cell.2013.05.002

XDynamics of hippocampal neurogenesis in adult humans

Kirsty L. Spalding, Olaf Bergmann, Kanar Alkass, Samuel Bernard, Mehran Salehpour, Hagen B. Huttner, Emil Boström, Isabelle Westerlund, Céline Vial, Bruce A. Buchholz, Göran Possnert, Deborah C. Mash, Henrik Druid, Jonas Frisén

Neurology

Research output: Contribution to journal › Article

918 Scopus citations

Abstract

Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived ¹⁴C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.

Original language	English (US)
Number of pages	1
Journal	Cell
Volume	153
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2013.05.002
State	Published - Jun 6 2013

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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Spalding, K. L., Bergmann, O., Alkass, K., Bernard, S., Salehpour, M., Huttner, H. B., Boström, E., Westerlund, I., Vial, C., Buchholz, B. A., Possnert, G., Mash, D. C., Druid, H., & Frisén, J. (2013). XDynamics of hippocampal neurogenesis in adult humans. Cell, 153(6). https://doi.org/10.1016/j.cell.2013.05.002

XDynamics of hippocampal neurogenesis in adult humans. / Spalding, Kirsty L.; Bergmann, Olaf; Alkass, Kanar; Bernard, Samuel; Salehpour, Mehran; Huttner, Hagen B.; Boström, Emil; Westerlund, Isabelle; Vial, Céline; Buchholz, Bruce A.; Possnert, Göran; Mash, Deborah C.; Druid, Henrik; Frisén, Jonas.

In: Cell, Vol. 153, No. 6, 06.06.2013.

Research output: Contribution to journal › Article

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abstract = "Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived 14C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.",

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