X-ray monitoring of laser interstitial thermotherapy (LITT) in ex vivo porcine tissue

A. M. Minhaj, F. Manns, P. J. Milne, D. B. Denham, Jr Salas N., J. M. Parel, D. S. Robinson

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations


Experiments on the feasibility of X-ray monitoring of laser interstitial thermotherapy (LITT) of breast cancer are presented. Digital images of heated tissue phantoms (including fatty porcine tissue and polyacrylamide/acrylate hydrogel), obtained from an X-ray stereotactic biopsy system, were analyzed for changes in pixel intensity. Tissue phantoms were heated either by a 980 nm diode laser or by resistive heating elements in a custom-made chamber. Analysis was conducted by evaluating the changes in average pixel intensity of regions of interest. Image constancy and stability of the X-ray system were also investigated. Slight changes (<5%) dependent on the temperature of the tissue phantom were observed, while changes caused by heat-induced tissue displacement and/or shrinkage were more significant (>10%).

Original languageEnglish (US)
Pages (from-to)500-507
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Jan 1 2001
EventLaser in Surgery: Advanced Characterization, Therapeutics, and Systems XI - San Jose,CA, United States
Duration: Jun 20 2001Jun 23 2001


  • Breast cancer
  • Laser hyperthermia
  • LITT
  • Mammography
  • Monitoring
  • Temperature

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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