X-linked neuropathy: Gene localization with DNA probes

K. H. Fischbeck, N. ar-Rushdi, Margaret A Pericak-Vance, M. Rozear, A. D. Roses, J. P. Fryns

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in four families with X-linked neuropathy. Despite clinical variability, all four families showed the same linkage pattern. We found evidence in each family of linkage to the marker DXYS1 on the proximal long arm of the X chromosome, as reported by others. We also found linkage to p58-1 (DXS14) on the proximal short arm. We fond only loose linkage or nonlinkage to nine other markers located elsewhere on the chromosome. Our analysis places the gene defect for this disorder in the region of DXYS1 and p58-1, near the centromere of the X chromosome.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalAnnals of Neurology
Volume20
Issue number4
StatePublished - Dec 30 1986
Externally publishedYes

Fingerprint

X-Linked Genes
DNA Probes
X Chromosome
Genetic Linkage
Centromere
Chromosomes
Genes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fischbeck, K. H., ar-Rushdi, N., Pericak-Vance, M. A., Rozear, M., Roses, A. D., & Fryns, J. P. (1986). X-linked neuropathy: Gene localization with DNA probes. Annals of Neurology, 20(4), 527-532.

X-linked neuropathy : Gene localization with DNA probes. / Fischbeck, K. H.; ar-Rushdi, N.; Pericak-Vance, Margaret A; Rozear, M.; Roses, A. D.; Fryns, J. P.

In: Annals of Neurology, Vol. 20, No. 4, 30.12.1986, p. 527-532.

Research output: Contribution to journalArticle

Fischbeck, KH, ar-Rushdi, N, Pericak-Vance, MA, Rozear, M, Roses, AD & Fryns, JP 1986, 'X-linked neuropathy: Gene localization with DNA probes', Annals of Neurology, vol. 20, no. 4, pp. 527-532.
Fischbeck KH, ar-Rushdi N, Pericak-Vance MA, Rozear M, Roses AD, Fryns JP. X-linked neuropathy: Gene localization with DNA probes. Annals of Neurology. 1986 Dec 30;20(4):527-532.
Fischbeck, K. H. ; ar-Rushdi, N. ; Pericak-Vance, Margaret A ; Rozear, M. ; Roses, A. D. ; Fryns, J. P. / X-linked neuropathy : Gene localization with DNA probes. In: Annals of Neurology. 1986 ; Vol. 20, No. 4. pp. 527-532.
@article{6a20fd1337404379bb145da774cab13c,
title = "X-linked neuropathy: Gene localization with DNA probes",
abstract = "We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in four families with X-linked neuropathy. Despite clinical variability, all four families showed the same linkage pattern. We found evidence in each family of linkage to the marker DXYS1 on the proximal long arm of the X chromosome, as reported by others. We also found linkage to p58-1 (DXS14) on the proximal short arm. We fond only loose linkage or nonlinkage to nine other markers located elsewhere on the chromosome. Our analysis places the gene defect for this disorder in the region of DXYS1 and p58-1, near the centromere of the X chromosome.",
author = "Fischbeck, {K. H.} and N. ar-Rushdi and Pericak-Vance, {Margaret A} and M. Rozear and Roses, {A. D.} and Fryns, {J. P.}",
year = "1986",
month = "12",
day = "30",
language = "English",
volume = "20",
pages = "527--532",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - X-linked neuropathy

T2 - Gene localization with DNA probes

AU - Fischbeck, K. H.

AU - ar-Rushdi, N.

AU - Pericak-Vance, Margaret A

AU - Rozear, M.

AU - Roses, A. D.

AU - Fryns, J. P.

PY - 1986/12/30

Y1 - 1986/12/30

N2 - We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in four families with X-linked neuropathy. Despite clinical variability, all four families showed the same linkage pattern. We found evidence in each family of linkage to the marker DXYS1 on the proximal long arm of the X chromosome, as reported by others. We also found linkage to p58-1 (DXS14) on the proximal short arm. We fond only loose linkage or nonlinkage to nine other markers located elsewhere on the chromosome. Our analysis places the gene defect for this disorder in the region of DXYS1 and p58-1, near the centromere of the X chromosome.

AB - We used probes for DNA polymorphisms on the X chromosome to study genetic linkage in four families with X-linked neuropathy. Despite clinical variability, all four families showed the same linkage pattern. We found evidence in each family of linkage to the marker DXYS1 on the proximal long arm of the X chromosome, as reported by others. We also found linkage to p58-1 (DXS14) on the proximal short arm. We fond only loose linkage or nonlinkage to nine other markers located elsewhere on the chromosome. Our analysis places the gene defect for this disorder in the region of DXYS1 and p58-1, near the centromere of the X chromosome.

UR - http://www.scopus.com/inward/record.url?scp=0022514979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022514979&partnerID=8YFLogxK

M3 - Article

C2 - 3024556

AN - SCOPUS:0022514979

VL - 20

SP - 527

EP - 532

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -