X-Arrestin: a new retinal arrestin mapping to the X chromosome

Akira Murakami, Toshihiro Yajima, Hitoshi Sakuma, Margaret J. McLaren, George Inana

Research output: Contribution to journalArticle

83 Scopus citations

Abstract

We have been using a differential cDNA cloning approach to isolate human retina-specific and retina-enriched genes [1]. A 1,314 bp cDNA was isolated by this approach, representing a highly retina-specific message encoding a 388 amino acid protein showing 58%, 50%, and 49% homology to bovine β-arrestin, and bovine and human retinal arrestin (S-antigen), respectively. Chromosomal mapping localized this new arrestin genc to the proximal long arm of the X chromosome, hence it was named X-arrestin. In situ hybridization demonstrated its expression in the inner and outer segments and the inner plexiform regions of the retina.

Original languageEnglish (US)
Pages (from-to)203-209
Number of pages7
JournalFEBS letters
Volume334
Issue number2
DOIs
StatePublished - Nov 15 1993

Keywords

  • Arrestin
  • cDNA
  • Hybridization, in situ
  • Retina
  • X chromosome
  • β-Arrestin

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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