TY - JOUR
T1 - Wound repair and regeneration
T2 - Mechanisms, signaling, and translation
AU - Eming, Sabine A.
AU - Martin, Paul
AU - Tomic-Canic, Marjana
N1 - Publisher Copyright:
© 2014, American Association for the Advancement of Science. All rights reserved.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/12/3
Y1 - 2014/12/3
N2 - The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
AB - The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
UR - http://www.scopus.com/inward/record.url?scp=84915789422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84915789422&partnerID=8YFLogxK
U2 - 10.1126/scitranslmed.3009337
DO - 10.1126/scitranslmed.3009337
M3 - Review article
C2 - 25473038
AN - SCOPUS:84915789422
VL - 6
JO - Science Translational Medicine
JF - Science Translational Medicine
SN - 1946-6234
IS - 265
M1 - 265sr6
ER -