Wound repair and regeneration: Mechanisms, signaling, and translation

Sabine A. Eming, Paul Martin, Marjana Tomic-Canic

Research output: Contribution to journalReview article

625 Scopus citations

Abstract

The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.

Original languageEnglish (US)
Article number265sr6
JournalScience Translational Medicine
Volume6
Issue number265
DOIs
StatePublished - Dec 3 2014

ASJC Scopus subject areas

  • Medicine(all)

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