Wound healing after filtering surgery in owl monkeys

D. C. Desjardins, Richard K Parrish, R. Folberg, J. Nevarez, D. K. Heuer, M. G. Gressel

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

We performed posterior lip sclerectomies in 29 owl monkey eyes to determine the natural history of wound healing after filtering surgery without adjunctive antimetabolite therapy. We noted three phases of wound healing during clinical and histologic examination: early healing (days 2 to 6), intermediate healing (days 7 to 9), and late healing (days 10 to 14). In the early healing phase, all limbal fistulas except one remained open gonioscopically, but by day 6, fibroblasts had proliferated along the walls of the opening. Proliferation and migration of fibroblasts continued during the intermediate healing phase to completely occlude four and to partially occlude two of the ten fistulas in the eyes studied during this time. In the late healing phase, the limbal fistula was completely closed by granulation tissue in four of five eyes and was slitlike open in one eye. In this model of filtering surgery, wound healing at the sclerectomy site with obliteration of the limbal opening by proliferating fibroblasts occurred within the first 14 postoperative days. We believe that the short-term effects of newer treatments designed to alter wound healing after filtering surgery may be assessed in this model, which is characterized by predictable and prompt wound healing.

Original languageEnglish
Pages (from-to)1835-1839
Number of pages5
JournalArchives of Ophthalmology
Volume104
Issue number12
StatePublished - Dec 1 1986
Externally publishedYes

Fingerprint

Aotidae
Filtering Surgery
Wound Healing
Fistula
Fibroblasts
Antimetabolites
Granulation Tissue
Lip
Natural History

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Desjardins, D. C., Parrish, R. K., Folberg, R., Nevarez, J., Heuer, D. K., & Gressel, M. G. (1986). Wound healing after filtering surgery in owl monkeys. Archives of Ophthalmology, 104(12), 1835-1839.

Wound healing after filtering surgery in owl monkeys. / Desjardins, D. C.; Parrish, Richard K; Folberg, R.; Nevarez, J.; Heuer, D. K.; Gressel, M. G.

In: Archives of Ophthalmology, Vol. 104, No. 12, 01.12.1986, p. 1835-1839.

Research output: Contribution to journalArticle

Desjardins, DC, Parrish, RK, Folberg, R, Nevarez, J, Heuer, DK & Gressel, MG 1986, 'Wound healing after filtering surgery in owl monkeys', Archives of Ophthalmology, vol. 104, no. 12, pp. 1835-1839.
Desjardins DC, Parrish RK, Folberg R, Nevarez J, Heuer DK, Gressel MG. Wound healing after filtering surgery in owl monkeys. Archives of Ophthalmology. 1986 Dec 1;104(12):1835-1839.
Desjardins, D. C. ; Parrish, Richard K ; Folberg, R. ; Nevarez, J. ; Heuer, D. K. ; Gressel, M. G. / Wound healing after filtering surgery in owl monkeys. In: Archives of Ophthalmology. 1986 ; Vol. 104, No. 12. pp. 1835-1839.
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