Wound Conforming Matrix Containing Purified Homogenate of Dermal Collagen Promotes Healing of Diabetic Neuropathic Foot Ulcers: Comparative Analysis Versus Standard of Care

Lois A. Chandler, Oscar M. Alvarez, Peter A. Blume, Paul J. Kim, Robert S. Kirsner, John C. Lantis, William A. Marston

Research output: Contribution to journalArticle

Abstract

Objective: To compare outcomes of diabetic foot ulcers (DFUs) treated with a collagen Wound Conforming Matrix (WCM) or standard of care (SOC). Approach: WCM, a highly purified homogenate of 2.6% fibrillar bovine dermal collagen that conforms to the wound surface, was evaluated in comparison to daily saline-moistened gauze dressing changes (SOC) as part of a retrospective subset analysis of a randomized controlled trial in DFU. Following a 2-week run-in period during which patients received SOC, patients whose wounds did not reduce in area by >30% during run-in were randomly assigned to receive WCM (one or two applications) or SOC. Results: Statistically significant acceleration of early healing rates was observed following a single application of WCM with weekly outer dressing changes compared with daily saline-moistened gauze dressing changes (SOC). Over a 4-week period, 50% of patients receiving a single application of WCM achieved ≥75% reduction in wound area compared with 13% for SOC. WCM appeared to be safe and well tolerated, with no adverse events related to treatment and no evidence of an immunologic reaction to bovine collagen. Innovation: WCM is unique in its intimate contact with the wound bed and its ability to progress a wound toward healing with a single application. Conclusion: WCM is a treatment modality to accelerate DFU healing rates, with the potential to reduce the likelihood of infection and other complications, and cost of care.

Original languageEnglish (US)
Pages (from-to)61-67
Number of pages7
JournalAdvances in Wound Care
Volume9
Issue number2
DOIs
StatePublished - Feb 2020

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Diabetic Foot
Standard of Care
Collagen
Skin
Wounds and Injuries
Bandages
Wound Healing
Randomized Controlled Trials

Keywords

  • collagen
  • diabetic foot ulcer
  • platelet activation
  • randomized controlled trial
  • wound healing rate

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Wound Conforming Matrix Containing Purified Homogenate of Dermal Collagen Promotes Healing of Diabetic Neuropathic Foot Ulcers : Comparative Analysis Versus Standard of Care. / Chandler, Lois A.; Alvarez, Oscar M.; Blume, Peter A.; Kim, Paul J.; Kirsner, Robert S.; Lantis, John C.; Marston, William A.

In: Advances in Wound Care, Vol. 9, No. 2, 02.2020, p. 61-67.

Research output: Contribution to journalArticle

Chandler, Lois A. ; Alvarez, Oscar M. ; Blume, Peter A. ; Kim, Paul J. ; Kirsner, Robert S. ; Lantis, John C. ; Marston, William A. / Wound Conforming Matrix Containing Purified Homogenate of Dermal Collagen Promotes Healing of Diabetic Neuropathic Foot Ulcers : Comparative Analysis Versus Standard of Care. In: Advances in Wound Care. 2020 ; Vol. 9, No. 2. pp. 61-67.
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abstract = "Objective: To compare outcomes of diabetic foot ulcers (DFUs) treated with a collagen Wound Conforming Matrix (WCM) or standard of care (SOC). Approach: WCM, a highly purified homogenate of 2.6{\%} fibrillar bovine dermal collagen that conforms to the wound surface, was evaluated in comparison to daily saline-moistened gauze dressing changes (SOC) as part of a retrospective subset analysis of a randomized controlled trial in DFU. Following a 2-week run-in period during which patients received SOC, patients whose wounds did not reduce in area by >30{\%} during run-in were randomly assigned to receive WCM (one or two applications) or SOC. Results: Statistically significant acceleration of early healing rates was observed following a single application of WCM with weekly outer dressing changes compared with daily saline-moistened gauze dressing changes (SOC). Over a 4-week period, 50{\%} of patients receiving a single application of WCM achieved ≥75{\%} reduction in wound area compared with 13{\%} for SOC. WCM appeared to be safe and well tolerated, with no adverse events related to treatment and no evidence of an immunologic reaction to bovine collagen. Innovation: WCM is unique in its intimate contact with the wound bed and its ability to progress a wound toward healing with a single application. Conclusion: WCM is a treatment modality to accelerate DFU healing rates, with the potential to reduce the likelihood of infection and other complications, and cost of care.",
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