Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis?

Xiaohua Song, Qi Ma, Xialin Liu, Pearl H Seo, Ed Herderick, Keith A Webster, Pascal Goldschmidt-Clermont, David M Seo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Maintenance of healthy arteries requires a balance between injuries to the arterial wall and processes of intrinsic arterial repair. Such repair requires the availability of progenitor cells that are local to the wall itself. Progenitor cells from distant reservoirs like the bone marrow may also contribute to repair. Arterial repair seems to degrade over a lifetime, particularly with risk factors such as smoking and diabetes. Hence, a potential preventive/therapeutic strategy for atherosclerosis could be transfusion of competent bone marrow cells (BMCs) to restore effective repair in the face of arterial injury and depleted endogenous repair reservoirs. The challenge with this strategy has been the reliable collection and/or generation of BMCs that support arterial repair. In this study, we describe a set of experiments to elucidate a method of culturing BMCs that robustly retards atherosclerosis development in apolipoprotein E knockout mice. Identifying such a method would represent an important step in developing cell-based treatments for patients with proclivity for developing atherosclerosis.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalAntioxidants and Redox Signaling
Volume16
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Intravenous Injections
Bone Marrow Cells
Atherosclerosis
Bone
Repair
Cells
Stem Cells
Wounds and Injuries
Apolipoproteins E
Knockout Mice
Arteries
Bone Marrow
Smoking
Maintenance
Therapeutics
Medical problems
Availability
Experiments

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis? / Song, Xiaohua; Ma, Qi; Liu, Xialin; Seo, Pearl H; Herderick, Ed; Webster, Keith A; Goldschmidt-Clermont, Pascal; Seo, David M.

In: Antioxidants and Redox Signaling, Vol. 16, No. 1, 01.01.2012, p. 85-91.

Research output: Contribution to journalArticle

Song, Xiaohua ; Ma, Qi ; Liu, Xialin ; Seo, Pearl H ; Herderick, Ed ; Webster, Keith A ; Goldschmidt-Clermont, Pascal ; Seo, David M. / Will periodic intravenous injections of conditioned bone marrow cells effectively reduce atherosclerosis?. In: Antioxidants and Redox Signaling. 2012 ; Vol. 16, No. 1. pp. 85-91.
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