Widefield en face optical coherence tomography imaging of subretinal drusenoid deposits

Karen B. Schaal, Andrew D. Legarreta, Giovanni Gregori, John E. Legarreta, Qianqian Cheng, Paul F. Stetson, Ming Cai, Michal Laron, Mary Durbin, Philip J Rosenfeld

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVE: To determine whether subretinal drusenoid deposits (SDD) can be detected on widefield en face slab images derived from spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) volume scans. PATIENTS AND METHODS: Retrospective study of patients with dry age-related macular degeneration (AMD) enrolled prospectively in an OCT imaging study using SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) with a central wavelength of 840 nm, and a prototype 100-kHz SS-OCT instrument (Carl Zeiss Meditec) with a central wavelength of 1,050 nm. Seven en face slabs were evaluated with thicknesses from 20 to 55 μm and positioned at distances up to 55 μm above the retinal pigment epithelium (RPE). A montage of 6 × 6 mm SD-OCT en face images of the posterior pole from each patient was compared with a 9 × 12 mm SS-OCT single en face slab image and with color, autofluorescence, and infrared reflectance images. RESULTS: A total of 160 patients (256 eyes) underwent scanning with both OCT instruments; 57 patients (95 eyes) also underwent multimodal fundus imaging. Of 95 eyes, 32 (34%) were diagnosed with reticular pseudodrusen (RPD) using multimodal imaging. All eyes with RPD demonstrated a pattern of SDD on widefield en face OCT similar to that observed for RPD. The en face slab image that consistently identified SDD was the 20-μm thick slab with boundaries from 35 to 55 μm above the RPE. CONCLUSION: Widefield en face slab imaging with SD-OCT and SS-OCT can detect SDD and could replace multimodal imaging for the diagnosis of RPD in the future.

Original languageEnglish (US)
Pages (from-to)550-559
Number of pages10
JournalOphthalmic Surgery Lasers and Imaging Retina
Volume46
Issue number5
DOIs
StatePublished - May 1 2015

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Optical Coherence Tomography
Multimodal Imaging
Retinal Pigment Epithelium
Macular Degeneration
Retrospective Studies
Color

ASJC Scopus subject areas

  • Ophthalmology
  • Surgery

Cite this

Widefield en face optical coherence tomography imaging of subretinal drusenoid deposits. / Schaal, Karen B.; Legarreta, Andrew D.; Gregori, Giovanni; Legarreta, John E.; Cheng, Qianqian; Stetson, Paul F.; Cai, Ming; Laron, Michal; Durbin, Mary; Rosenfeld, Philip J.

In: Ophthalmic Surgery Lasers and Imaging Retina, Vol. 46, No. 5, 01.05.2015, p. 550-559.

Research output: Contribution to journalArticle

Schaal, Karen B. ; Legarreta, Andrew D. ; Gregori, Giovanni ; Legarreta, John E. ; Cheng, Qianqian ; Stetson, Paul F. ; Cai, Ming ; Laron, Michal ; Durbin, Mary ; Rosenfeld, Philip J. / Widefield en face optical coherence tomography imaging of subretinal drusenoid deposits. In: Ophthalmic Surgery Lasers and Imaging Retina. 2015 ; Vol. 46, No. 5. pp. 550-559.
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abstract = "BACKGROUND AND OBJECTIVE: To determine whether subretinal drusenoid deposits (SDD) can be detected on widefield en face slab images derived from spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) volume scans. PATIENTS AND METHODS: Retrospective study of patients with dry age-related macular degeneration (AMD) enrolled prospectively in an OCT imaging study using SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) with a central wavelength of 840 nm, and a prototype 100-kHz SS-OCT instrument (Carl Zeiss Meditec) with a central wavelength of 1,050 nm. Seven en face slabs were evaluated with thicknesses from 20 to 55 μm and positioned at distances up to 55 μm above the retinal pigment epithelium (RPE). A montage of 6 × 6 mm SD-OCT en face images of the posterior pole from each patient was compared with a 9 × 12 mm SS-OCT single en face slab image and with color, autofluorescence, and infrared reflectance images. RESULTS: A total of 160 patients (256 eyes) underwent scanning with both OCT instruments; 57 patients (95 eyes) also underwent multimodal fundus imaging. Of 95 eyes, 32 (34{\%}) were diagnosed with reticular pseudodrusen (RPD) using multimodal imaging. All eyes with RPD demonstrated a pattern of SDD on widefield en face OCT similar to that observed for RPD. The en face slab image that consistently identified SDD was the 20-μm thick slab with boundaries from 35 to 55 μm above the RPE. CONCLUSION: Widefield en face slab imaging with SD-OCT and SS-OCT can detect SDD and could replace multimodal imaging for the diagnosis of RPD in the future.",
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AU - Schaal, Karen B.

AU - Legarreta, Andrew D.

AU - Gregori, Giovanni

AU - Legarreta, John E.

AU - Cheng, Qianqian

AU - Stetson, Paul F.

AU - Cai, Ming

AU - Laron, Michal

AU - Durbin, Mary

AU - Rosenfeld, Philip J

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AB - BACKGROUND AND OBJECTIVE: To determine whether subretinal drusenoid deposits (SDD) can be detected on widefield en face slab images derived from spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) volume scans. PATIENTS AND METHODS: Retrospective study of patients with dry age-related macular degeneration (AMD) enrolled prospectively in an OCT imaging study using SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA) with a central wavelength of 840 nm, and a prototype 100-kHz SS-OCT instrument (Carl Zeiss Meditec) with a central wavelength of 1,050 nm. Seven en face slabs were evaluated with thicknesses from 20 to 55 μm and positioned at distances up to 55 μm above the retinal pigment epithelium (RPE). A montage of 6 × 6 mm SD-OCT en face images of the posterior pole from each patient was compared with a 9 × 12 mm SS-OCT single en face slab image and with color, autofluorescence, and infrared reflectance images. RESULTS: A total of 160 patients (256 eyes) underwent scanning with both OCT instruments; 57 patients (95 eyes) also underwent multimodal fundus imaging. Of 95 eyes, 32 (34%) were diagnosed with reticular pseudodrusen (RPD) using multimodal imaging. All eyes with RPD demonstrated a pattern of SDD on widefield en face OCT similar to that observed for RPD. The en face slab image that consistently identified SDD was the 20-μm thick slab with boundaries from 35 to 55 μm above the RPE. CONCLUSION: Widefield en face slab imaging with SD-OCT and SS-OCT can detect SDD and could replace multimodal imaging for the diagnosis of RPD in the future.

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