Abstract
In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
| Original language | English (US) |
|---|---|
| Article number | e1002200 |
| Journal | PLoS computational biology |
| Volume | 7 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2011 |
ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Modeling and Simulation
- Ecology
- Molecular Biology
- Genetics
- Cellular and Molecular Neuroscience
- Computational Theory and Mathematics
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Cite this
Elemans, M., al Basatena, N. K. S., Klatt, N. R., Gkekas, C., Silvestri, G., & Asquith, B. (2011). Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? PLoS computational biology, 7(9), [e1002200]. https://doi.org/10.1371/journal.pcbi.1002200