Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?

Marjet Elemans, Nafisa Katrin Seich al Basatena, Nichole R. Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.

Original languageEnglish (US)
Article numbere1002200
JournalPLoS computational biology
Volume7
Issue number9
DOIs
StatePublished - Sep 2011

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

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    Elemans, M., al Basatena, N. K. S., Klatt, N. R., Gkekas, C., Silvestri, G., & Asquith, B. (2011). Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? PLoS computational biology, 7(9), [e1002200]. https://doi.org/10.1371/journal.pcbi.1002200