Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?

Marjet Elemans, Nafisa Katrin Seich al Basatena, Nichole Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.

Original languageEnglish (US)
Article numbere1002200
JournalPLoS Computational Biology
Volume7
Issue number9
DOIs
StatePublished - Sep 1 2011
Externally publishedYes

Fingerprint

T-cells
Life Span
T-lymphocytes
T-Lymphocytes
Cell
experiment
cells
Viremia
viremia
Macaca
Depletion
Observation
Alternatives
Experiment
Experiments
Model

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

Cite this

Elemans, M., al Basatena, N. K. S., Klatt, N., Gkekas, C., Silvestri, G., & Asquith, B. (2011). Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? PLoS Computational Biology, 7(9), [e1002200]. https://doi.org/10.1371/journal.pcbi.1002200

Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? / Elemans, Marjet; al Basatena, Nafisa Katrin Seich; Klatt, Nichole; Gkekas, Christos; Silvestri, Guido; Asquith, Becca.

In: PLoS Computational Biology, Vol. 7, No. 9, e1002200, 01.09.2011.

Research output: Contribution to journalArticle

Elemans, M, al Basatena, NKS, Klatt, N, Gkekas, C, Silvestri, G & Asquith, B 2011, 'Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?', PLoS Computational Biology, vol. 7, no. 9, e1002200. https://doi.org/10.1371/journal.pcbi.1002200
Elemans, Marjet ; al Basatena, Nafisa Katrin Seich ; Klatt, Nichole ; Gkekas, Christos ; Silvestri, Guido ; Asquith, Becca. / Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?. In: PLoS Computational Biology. 2011 ; Vol. 7, No. 9.
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