Abstract
In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
| Original language | English (US) |
|---|---|
| Article number | e1002200 |
| Journal | PLoS Computational Biology |
| Volume | 7 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Ecology, Evolution, Behavior and Systematics
- Modeling and Simulation
- Ecology
- Molecular Biology
- Genetics
- Cellular and Molecular Neuroscience
- Computational Theory and Mathematics
Cite this
Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? / Elemans, Marjet; al Basatena, Nafisa Katrin Seich; Klatt, Nichole; Gkekas, Christos; Silvestri, Guido; Asquith, Becca.
In: PLoS Computational Biology, Vol. 7, No. 9, e1002200, 01.09.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?
AU - Elemans, Marjet
AU - al Basatena, Nafisa Katrin Seich
AU - Klatt, Nichole
AU - Gkekas, Christos
AU - Silvestri, Guido
AU - Asquith, Becca
PY - 2011/9/1
Y1 - 2011/9/1
N2 - In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
AB - In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
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UR - http://www.scopus.com/inward/citedby.url?scp=80053452357&partnerID=8YFLogxK
U2 - 10.1371/journal.pcbi.1002200
DO - 10.1371/journal.pcbi.1002200
M3 - Article
C2 - 21990968
AN - SCOPUS:80053452357
VL - 7
JO - PLoS Computational Biology
JF - PLoS Computational Biology
SN - 1553-734X
IS - 9
M1 - e1002200
ER -