Whole kidney engineering for clinical translation

Ick Hee Kim, In Kap Ko, Anthony Atala, James J. Yoo

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Purpose of review Renal transplantation is currently the only definitive treatment for end-stage renal disease; however, this treatment is severely limited by the shortage of implantable kidneys. To address this shortcoming, development of an engineered, transplantable kidney has been proposed. Although current advances in engineering kidneys based on decellularization and recellularization techniques have offered great promises for the generation of functional kidney constructs, most studies have been conducted using rodent kidney constructs and short-term in-vivo evaluation. Toward clinical translations of this technique, several limitations need to be addressed. Recent findings Human-sized renal scaffolds are desirable for clinical application, and the fabrication is currently feasible using native porcine and discarded human kidneys. Current progress in stem cell biology and cell culture methods have demonstrated feasibility of the use of embryonic stem cells, induced pluripotent stem cells, and primary renal cells as clinically relevant cell sources for the recellularization of renal scaffolds. Finally, approaches to long-term implantation of engineered kidneys are under investigation using antithrombogenic strategies such as functional reendothelialization of acellular kidney matrices. Summary In the field of bioengineering, whole kidneys have taken a number of important initial steps toward clinical translations, but many challenges must be addressed to achieve a successful treatment for the patient with end-stage renal disease.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalCurrent Opinion in Organ Transplantation
Volume20
Issue number2
DOIs
StatePublished - Jan 1 2015

Keywords

  • cell sources
  • clinical translation
  • decellularization
  • kidney scaffolds
  • long-term implantation
  • recellularization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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