Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge

J. D. Lifson; M. Piatak; J. L. Rossio; J. Bess; E. Chertova; D. Schneider; R. Kiser; V. Coalter; B. Poore; R. Imming; R. C. Desrosiers; L. E. Henderson; L. O. Arthur

doi:10.1034/j.1600-0684.2002.02007.x

Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge

J. D. Lifson, M. Piatak, J. L. Rossio, J. Bess, E. Chertova, D. Schneider, R. Kiser, V. Coalter, B. Poore, R. Imming, R. C. Desrosiers, L. E. Henderson, L. O. Arthur

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

A novel type of whole inactivated simian immunodeficiency virus (SIV) virion vaccine immunogen with functional envelope glycoproteins was evaluated, without adjuvant, in rhesus macaques. Immunogens included purified inactivated virions of SIVmac239, a designed mutant of SIVmac239 with gp120 carbohydrate attachment sites deleted (SIVmac239 g4,5), and SIVmneE11S. The vaccines were noninfectious, safe, and immunogenic, inducing antibody responses and cellular responses, including responses by CD8+ lymphocytes. Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naïve controls.

Original language	English (US)
Pages (from-to)	205-216
Number of pages	12
Journal	Journal of medical primatology
Volume	31
Issue number	4-5
DOIs	https://doi.org/10.1034/j.1600-0684.2002.02007.x
State	Published - Aug 2002
Externally published	Yes

Keywords

Inactivated
SIV
Vaccine

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1034/j.1600-0684.2002.02007.x

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Lifson, J. D., Piatak, M., Rossio, J. L., Bess, J., Chertova, E., Schneider, D., Kiser, R., Coalter, V., Poore, B., Imming, R., Desrosiers, R. C., Henderson, L. E., & Arthur, L. O. (2002). Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge. Journal of medical primatology, 31(4-5), 205-216. https://doi.org/10.1034/j.1600-0684.2002.02007.x

Whole inactivated SIV virion vaccines with functional envelope glycoproteins : Safety, immunogenicity, and activity against intrarectal challenge. / Lifson, J. D.; Piatak, M.; Rossio, J. L.; Bess, J.; Chertova, E.; Schneider, D.; Kiser, R.; Coalter, V.; Poore, B.; Imming, R.; Desrosiers, R. C.; Henderson, L. E.; Arthur, L. O.

In: Journal of medical primatology, Vol. 31, No. 4-5, 08.2002, p. 205-216.

Research output: Contribution to journal › Article › peer-review

Lifson, JD, Piatak, M, Rossio, JL, Bess, J, Chertova, E, Schneider, D, Kiser, R, Coalter, V, Poore, B, Imming, R, Desrosiers, RC, Henderson, LE & Arthur, LO 2002, 'Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge', Journal of medical primatology, vol. 31, no. 4-5, pp. 205-216. https://doi.org/10.1034/j.1600-0684.2002.02007.x

Lifson, J. D. ; Piatak, M. ; Rossio, J. L. ; Bess, J. ; Chertova, E. ; Schneider, D. ; Kiser, R. ; Coalter, V. ; Poore, B. ; Imming, R. ; Desrosiers, R. C. ; Henderson, L. E. ; Arthur, L. O. / Whole inactivated SIV virion vaccines with functional envelope glycoproteins : Safety, immunogenicity, and activity against intrarectal challenge. In: Journal of medical primatology. 2002 ; Vol. 31, No. 4-5. pp. 205-216.

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abstract = "A novel type of whole inactivated simian immunodeficiency virus (SIV) virion vaccine immunogen with functional envelope glycoproteins was evaluated, without adjuvant, in rhesus macaques. Immunogens included purified inactivated virions of SIVmac239, a designed mutant of SIVmac239 with gp120 carbohydrate attachment sites deleted (SIVmac239 g4,5), and SIVmneE11S. The vaccines were noninfectious, safe, and immunogenic, inducing antibody responses and cellular responses, including responses by CD8+ lymphocytes. Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV na{\"i}ve controls.",

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AU - Kiser, R.

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