Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge

J. D. Lifson, M. Piatak, J. L. Rossio, J. Bess, E. Chertova, D. Schneider, R. Kiser, V. Coalter, B. Poore, R. Imming, R. C. Desrosiers, L. E. Henderson, L. O. Arthur

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

A novel type of whole inactivated simian immunodeficiency virus (SIV) virion vaccine immunogen with functional envelope glycoproteins was evaluated, without adjuvant, in rhesus macaques. Immunogens included purified inactivated virions of SIVmac239, a designed mutant of SIVmac239 with gp120 carbohydrate attachment sites deleted (SIVmac239 g4,5), and SIVmneE11S. The vaccines were noninfectious, safe, and immunogenic, inducing antibody responses and cellular responses, including responses by CD8+ lymphocytes. Interpretation of protective efficacy following intrarectal challenge was complicated by incomplete take of the challenge in some SIV naïve controls.

Original languageEnglish (US)
Pages (from-to)205-216
Number of pages12
JournalJournal of medical primatology
Volume31
Issue number4-5
DOIs
StatePublished - Aug 1 2002
Externally publishedYes

Keywords

  • Inactivated
  • SIV
  • Vaccine

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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    Lifson, J. D., Piatak, M., Rossio, J. L., Bess, J., Chertova, E., Schneider, D., Kiser, R., Coalter, V., Poore, B., Imming, R., Desrosiers, R. C., Henderson, L. E., & Arthur, L. O. (2002). Whole inactivated SIV virion vaccines with functional envelope glycoproteins: Safety, immunogenicity, and activity against intrarectal challenge. Journal of medical primatology, 31(4-5), 205-216. https://doi.org/10.1034/j.1600-0684.2002.02007.x