TY - JOUR
T1 - Whole eye axial biometry during accommodation using ultra-long scan depth optical coherence tomography
AU - Zhong, Jianguang
AU - Tao, Aizhu
AU - Xu, Zhe
AU - Jiang, Hong
AU - Shao, Yilei
AU - Zhang, Huicheng
AU - Liu, Che
AU - Wang, Jianhua
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. The authors report the following financial disclosure: The University of Miami and Dr Wang hold a provisional patent (WO 2013/081902) used in the study. This study was supported by research grants in part from the NIH (EY021012, EY021336, and EY020607S), NIH Center Grant P30 EY014801, Research to Prevent Blindness (RPB). A visiting scholar award for Dr Jianguang Zhong was provided by the Hangzhou First People's Hospital, Hangzhou, China. The funding organizations had no role in the design or conduct of this study. Contributions of the authors: design of the study (J.Z., J.W., Y.S., A.T., H.J., C.L., H.Z.); data collection (J.Z., Y.S., A.T., J.W.); analysis and interpretation of the data (J.Z., J.W., Y.S., A.T., H.J., C.L., H.Z., Z.X.); preparation, review, and approval of the manuscript (J.Z., J.W., Y.S., A.T., H.J., C.L., H.Z., Z.X.).
PY - 2014/5
Y1 - 2014/5
N2 - Purpose To investigate changes of whole eye axial biometry during accommodation using ultra-long scan depth optical coherence tomography (UL-OCT). Design Prospective, observational case series. Methods Twenty-one adult subjects were enrolled. Using UL-OCT, the left eye of each subject was imaged with relaxed diopters (0 D) and accommodative stimuli (+6 D). Full eye biometry included central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness, vitreous length, and axial length (AL). Results During accommodation (+6 D), the axial biometry of the whole eye changed significantly. Compared to the rest state, ACD at the accommodative state decreased significantly from 3.128 ± 0.305 mm to 2.961 ± 0.298 mm (paired t test, P <.001). The lens thickness increased significantly from 3.723 ± 0.237 mm to 3.963 ± 0.234 mm (P <.001). The vitreous length decreased significantly from 17.129 ± 0.864 mm to 17.057 ± 0.848 mm (P <.001). AL was 24.519 ± 0.917 mm at the rest state and increased to 24.545 ± 0.915 mm with +6 D accommodation stimulus. The elongated AL of 26.1 ± 13.4 μm between the rest and accommodative states was significant (P <.001). Conclusions During accommodation, whole eye axial biometry changed, including a decrease in ACD and vitreous length and an increase in lens thickness and AL. UL-OCT provides an alternative method that is suitable for full eye biometry during accommodation.
AB - Purpose To investigate changes of whole eye axial biometry during accommodation using ultra-long scan depth optical coherence tomography (UL-OCT). Design Prospective, observational case series. Methods Twenty-one adult subjects were enrolled. Using UL-OCT, the left eye of each subject was imaged with relaxed diopters (0 D) and accommodative stimuli (+6 D). Full eye biometry included central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness, vitreous length, and axial length (AL). Results During accommodation (+6 D), the axial biometry of the whole eye changed significantly. Compared to the rest state, ACD at the accommodative state decreased significantly from 3.128 ± 0.305 mm to 2.961 ± 0.298 mm (paired t test, P <.001). The lens thickness increased significantly from 3.723 ± 0.237 mm to 3.963 ± 0.234 mm (P <.001). The vitreous length decreased significantly from 17.129 ± 0.864 mm to 17.057 ± 0.848 mm (P <.001). AL was 24.519 ± 0.917 mm at the rest state and increased to 24.545 ± 0.915 mm with +6 D accommodation stimulus. The elongated AL of 26.1 ± 13.4 μm between the rest and accommodative states was significant (P <.001). Conclusions During accommodation, whole eye axial biometry changed, including a decrease in ACD and vitreous length and an increase in lens thickness and AL. UL-OCT provides an alternative method that is suitable for full eye biometry during accommodation.
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U2 - 10.1016/j.ajo.2014.01.016
DO - 10.1016/j.ajo.2014.01.016
M3 - Article
C2 - 24487051
AN - SCOPUS:84898909699
VL - 157
SP - 1064-1069.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 5
ER -