Whole-brain radiotherapy in patients with brain metastases from melanoma

Macarena de la Fuente, Kathryn Beal, Richard Carvajal, Thomas J. Kaley

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

AIMS: To describe results of melanoma brain metastases (BM) treated with whole-brain radiation (WBRT).

METHODS: Retrospective review of patients with melanoma BM treated with WBRT divided into two groups based on the timing of WBRT (at BM diagnosis or recurrence).

RESULTS: We identified 61 patients with melanoma BM who received WBRT. For the group treated at diagnosis (n = 39): median overall survival was 3 months; best radiographic response included one partial response, ten stable disease, 18 progressive disease, and ten no follow-up imaging. For the group treated at recurrence (n = 22): median overall survival was 3 months; best radiographic response was three partial response, four stable disease, eight progressive disease, and seven no follow-up imaging.

CONCLUSION: WBRT activity was limited; however, its role in symptom palliation is unclear.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalCNS oncology
Volume3
Issue number6
DOIs
StatePublished - Nov 1 2014

Keywords

  • WBRT
  • brain metastases
  • ipilimumab
  • melanoma
  • overall survival
  • radiographic response

ASJC Scopus subject areas

  • Medicine(all)

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