Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI

Angèle Lecocq, Yann Le Fur, Andrew A Maudsley, Arnaud Le Troter, Sulaiman Sheriff, Mohamad Sabati, Maxime Donnadieu, Sylviane Confort-Gouny, Patrick J. Cozzone, Maxime Guye, Jean Philippe Ranjeva

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background To improve the extent over which whole brain quantitative three-dimensional (3D) magnetic resonance spectroscopic imaging (MRSI) maps can be obtained and be used to explore brain metabolism in a population of healthy volunteers. Methods Two short echo time (20 ms) acquisitions of 3D echo planar spectroscopic imaging at two orientations, one in the anterior commissure-posterior commissure (AC-PC) plane and the second tilted in the AC-PC +15° plane were obtained at 3 Tesla in a group of 10 healthy volunteers. B<inf>1</inf><sup>+</sup>, B<inf>1</inf><sup>-</sup>, and B<inf>0</inf> correction procedures and normalization of metabolite signals with quantitative water proton density measurements were performed. A combination of the two spatially normalized 3D-MRSI, using a weighted mean based on the pixel wise standard deviation metabolic maps of each orientation obtained from the whole group, provided metabolite maps for each subject allowing regional metabolic profiles of all parcels of the automated anatomical labeling (AAL) atlas to be obtained. Results The combined metabolite maps derived from the two acquisitions reduced the regional intersubject variance. The numbers of AAL regions showing N-acetyl aspartate (NAA) SD/Mean ratios lower than 30% increased from 17 in the AC-PC orientation and 41 in the AC-PC+15° orientation, to a value of 76 regions of 116 for the combined NAA maps. Quantitatively, regional differences in absolute metabolite concentrations (mM) over the whole brain were depicted such as in the GM of frontal lobes (c<inf>NAA</inf>-=-10.03-+-1.71; c<inf>Cho</inf>-=-1.78-±-0.55; c<inf>Cr</inf>-=-7.29-±-1.69; c<inf>mIns</inf>-=-5.30-±-2.67) and in cerebellum (c<inf>NAA</inf>-=-5.28-±-1.77; c<inf>Cho</inf>-=-1.60-±-0.41; c<inf>Cr</inf>-=-6.95-±-2.15; c<inf>mIns</inf>-=-3.60-±-0.74). Conclusion A double-angulation acquisition enables improved metabolic characterization over a wide volume of the brain.

Original languageEnglish (US)
Pages (from-to)280-289
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume42
Issue number2
DOIs
StatePublished - Aug 1 2015

Keywords

  • metabolite maps
  • MRSI
  • proton MR spectroscopy
  • template
  • whole brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI'. Together they form a unique fingerprint.

  • Cite this

    Lecocq, A., Le Fur, Y., Maudsley, A. A., Le Troter, A., Sheriff, S., Sabati, M., Donnadieu, M., Confort-Gouny, S., Cozzone, P. J., Guye, M., & Ranjeva, J. P. (2015). Whole-brain quantitative mapping of metabolites using short echo three-dimensional proton MRSI. Journal of Magnetic Resonance Imaging, 42(2), 280-289. https://doi.org/10.1002/jmri.24809