Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits

Varan Govind, Stuart Gold, Krithica Kaliannan, Gaurav Saigal, Steven Falcone, Kristopher Arheart, Leo Harris, Jonathan Jagid, Andrew A Maudsley

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

Changes in the distribution of the magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cre), following mild-to-moderate closed-head traumatic brain injury (mTBI) were evaluated using volumetric proton MR spectroscopic imaging (MRSI). Studies were carried out during the subacute time period following injury, and associations of metabolite indices with neuropsychological test (NPT) results were evaluated. Twenty-nine subjects with mTBI and Glasgow Coma Scale (GCS) scores of 10-15 were included. Differences in individual metabolite and metabolite ratio distributions relative to those of age-matched control subjects were evaluated, as well as analyses by hemispheric lobes and tissue types. Primary findings included a widespread decrease of NAA and NAA/Cre, and increases of Cho and Cho/NAA, within all lobes of the TBI subject group, and with the largest differences seen in white matter. Examination of the association between all of the metabolite measures and the NPT scores found the strongest negative correlations to occur in the frontal lobe and for Cho/NAA. No significant correlations were found between any of the MRSI or NPT measures and the GCS. These results demonstrate that significant and widespread alterations of brain metabolites occur as a result of mild-to-moderate TBI, and that these measures correlate with measures of cognitive performance.

Original languageEnglish
Pages (from-to)483-496
Number of pages14
JournalJournal of Neurotrauma
Volume27
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Protons
Choline
Magnetic Resonance Imaging
Neuropsychological Tests
Brain
Glasgow Coma Scale
Creatine
Frontal Lobe
Individuality
Magnetic Resonance Spectroscopy
Head
Traumatic Brain Injury
N-acetylaspartate
Wounds and Injuries

Keywords

  • Brain
  • Magnetic resonance spectroscopic imaging
  • Magnetic resonance spectroscopy
  • Neuropsychological test
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits. / Govind, Varan; Gold, Stuart; Kaliannan, Krithica; Saigal, Gaurav; Falcone, Steven; Arheart, Kristopher; Harris, Leo; Jagid, Jonathan; Maudsley, Andrew A.

In: Journal of Neurotrauma, Vol. 27, No. 3, 01.03.2010, p. 483-496.

Research output: Contribution to journalArticle

@article{6ee6fab07e464434ace8ff0bac46ce17,
title = "Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits",
abstract = "Changes in the distribution of the magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cre), following mild-to-moderate closed-head traumatic brain injury (mTBI) were evaluated using volumetric proton MR spectroscopic imaging (MRSI). Studies were carried out during the subacute time period following injury, and associations of metabolite indices with neuropsychological test (NPT) results were evaluated. Twenty-nine subjects with mTBI and Glasgow Coma Scale (GCS) scores of 10-15 were included. Differences in individual metabolite and metabolite ratio distributions relative to those of age-matched control subjects were evaluated, as well as analyses by hemispheric lobes and tissue types. Primary findings included a widespread decrease of NAA and NAA/Cre, and increases of Cho and Cho/NAA, within all lobes of the TBI subject group, and with the largest differences seen in white matter. Examination of the association between all of the metabolite measures and the NPT scores found the strongest negative correlations to occur in the frontal lobe and for Cho/NAA. No significant correlations were found between any of the MRSI or NPT measures and the GCS. These results demonstrate that significant and widespread alterations of brain metabolites occur as a result of mild-to-moderate TBI, and that these measures correlate with measures of cognitive performance.",
keywords = "Brain, Magnetic resonance spectroscopic imaging, Magnetic resonance spectroscopy, Neuropsychological test, Traumatic brain injury",
author = "Varan Govind and Stuart Gold and Krithica Kaliannan and Gaurav Saigal and Steven Falcone and Kristopher Arheart and Leo Harris and Jonathan Jagid and Maudsley, {Andrew A}",
year = "2010",
month = "3",
day = "1",
doi = "10.1089/neu.2009.1159",
language = "English",
volume = "27",
pages = "483--496",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "3",

}

TY - JOUR

T1 - Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits

AU - Govind, Varan

AU - Gold, Stuart

AU - Kaliannan, Krithica

AU - Saigal, Gaurav

AU - Falcone, Steven

AU - Arheart, Kristopher

AU - Harris, Leo

AU - Jagid, Jonathan

AU - Maudsley, Andrew A

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Changes in the distribution of the magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cre), following mild-to-moderate closed-head traumatic brain injury (mTBI) were evaluated using volumetric proton MR spectroscopic imaging (MRSI). Studies were carried out during the subacute time period following injury, and associations of metabolite indices with neuropsychological test (NPT) results were evaluated. Twenty-nine subjects with mTBI and Glasgow Coma Scale (GCS) scores of 10-15 were included. Differences in individual metabolite and metabolite ratio distributions relative to those of age-matched control subjects were evaluated, as well as analyses by hemispheric lobes and tissue types. Primary findings included a widespread decrease of NAA and NAA/Cre, and increases of Cho and Cho/NAA, within all lobes of the TBI subject group, and with the largest differences seen in white matter. Examination of the association between all of the metabolite measures and the NPT scores found the strongest negative correlations to occur in the frontal lobe and for Cho/NAA. No significant correlations were found between any of the MRSI or NPT measures and the GCS. These results demonstrate that significant and widespread alterations of brain metabolites occur as a result of mild-to-moderate TBI, and that these measures correlate with measures of cognitive performance.

AB - Changes in the distribution of the magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cre), following mild-to-moderate closed-head traumatic brain injury (mTBI) were evaluated using volumetric proton MR spectroscopic imaging (MRSI). Studies were carried out during the subacute time period following injury, and associations of metabolite indices with neuropsychological test (NPT) results were evaluated. Twenty-nine subjects with mTBI and Glasgow Coma Scale (GCS) scores of 10-15 were included. Differences in individual metabolite and metabolite ratio distributions relative to those of age-matched control subjects were evaluated, as well as analyses by hemispheric lobes and tissue types. Primary findings included a widespread decrease of NAA and NAA/Cre, and increases of Cho and Cho/NAA, within all lobes of the TBI subject group, and with the largest differences seen in white matter. Examination of the association between all of the metabolite measures and the NPT scores found the strongest negative correlations to occur in the frontal lobe and for Cho/NAA. No significant correlations were found between any of the MRSI or NPT measures and the GCS. These results demonstrate that significant and widespread alterations of brain metabolites occur as a result of mild-to-moderate TBI, and that these measures correlate with measures of cognitive performance.

KW - Brain

KW - Magnetic resonance spectroscopic imaging

KW - Magnetic resonance spectroscopy

KW - Neuropsychological test

KW - Traumatic brain injury

UR - http://www.scopus.com/inward/record.url?scp=77950617072&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950617072&partnerID=8YFLogxK

U2 - 10.1089/neu.2009.1159

DO - 10.1089/neu.2009.1159

M3 - Article

VL - 27

SP - 483

EP - 496

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 3

ER -