Whole-Brain Proton MR Spectroscopic Imaging in Parkinson's Disease

Bonnie Levin, Heather L. Katzen, Andrew A Maudsley, M. Judith Post, Connie Myerson, Varan Govind, Fatta Nahab, Blake Scanlon, Aaron Mittel

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE: To examine the distributions of proton magnetic resonance spectroscopy (MRS) observed metabolites in Parkinson's disease (PD) throughout the whole brain. METHODS: Twelve PD patients and 18 age-matched controls were studied using neuropsychological testing, MRI and volumetric MR spectroscopic imaging. Average values of signal normalized metabolite values for N-acetyl-aspartate, total-creatine, and total-choline (NAA, total-Cre, total-Cho, respectively) and their ratios were calculated for gray matter (GM) and white matter (WM) in each lobar brain region. RESULTS: Analyses revealed altered metabolite values in PD subjects relative to controls within the GM of the temporal lobe (right: elevated Cre, P = .027; decreased NAA/Cre, P = .019; decreased Cho/Cre, P = .001 and left: decreased NAA/Cre; P = .001, decreased Cho/Cre, P = .007); the right occipital lobe (decreased NAA, P = .032 and NAA/Cre, P = .016); and the total cerebrum GM (decreased NAA/Cre, P = .029). No meaningful correlations were obtained between abnormal metabolite values and the neuropsychological measures. CONCLUSIONS: PD is associated with widespread alterations of brain metabolite concentrations, with a primary finding of increased creatine. Higher creatine values in our PD sample may reflect greater neuronal energy expenditure early in the disease process that is compensatory. This is the first whole brain MRS study of PD that has examined metabolite changes across a large fraction of the brain volume, including the cortical mantle.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalJournal of Neuroimaging
Volume24
Issue number1
DOIs
StatePublished - Jan 1 2014

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Parkinson Disease
Protons
Creatine
Brain
Occipital Lobe
Cerebrum
Temporal Lobe
Choline
Energy Metabolism
Magnetic Resonance Spectroscopy
Gray Matter

Keywords

  • Cognition
  • MRS/imaging
  • Parkinson's disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this

Whole-Brain Proton MR Spectroscopic Imaging in Parkinson's Disease. / Levin, Bonnie; Katzen, Heather L.; Maudsley, Andrew A; Judith Post, M.; Myerson, Connie; Govind, Varan; Nahab, Fatta; Scanlon, Blake; Mittel, Aaron.

In: Journal of Neuroimaging, Vol. 24, No. 1, 01.01.2014, p. 39-44.

Research output: Contribution to journalArticle

Levin, B, Katzen, HL, Maudsley, AA, Judith Post, M, Myerson, C, Govind, V, Nahab, F, Scanlon, B & Mittel, A 2014, 'Whole-Brain Proton MR Spectroscopic Imaging in Parkinson's Disease', Journal of Neuroimaging, vol. 24, no. 1, pp. 39-44. https://doi.org/10.1111/j.1552-6569.2012.00733.x
Levin, Bonnie ; Katzen, Heather L. ; Maudsley, Andrew A ; Judith Post, M. ; Myerson, Connie ; Govind, Varan ; Nahab, Fatta ; Scanlon, Blake ; Mittel, Aaron. / Whole-Brain Proton MR Spectroscopic Imaging in Parkinson's Disease. In: Journal of Neuroimaging. 2014 ; Vol. 24, No. 1. pp. 39-44.
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AB - BACKGROUND AND PURPOSE: To examine the distributions of proton magnetic resonance spectroscopy (MRS) observed metabolites in Parkinson's disease (PD) throughout the whole brain. METHODS: Twelve PD patients and 18 age-matched controls were studied using neuropsychological testing, MRI and volumetric MR spectroscopic imaging. Average values of signal normalized metabolite values for N-acetyl-aspartate, total-creatine, and total-choline (NAA, total-Cre, total-Cho, respectively) and their ratios were calculated for gray matter (GM) and white matter (WM) in each lobar brain region. RESULTS: Analyses revealed altered metabolite values in PD subjects relative to controls within the GM of the temporal lobe (right: elevated Cre, P = .027; decreased NAA/Cre, P = .019; decreased Cho/Cre, P = .001 and left: decreased NAA/Cre; P = .001, decreased Cho/Cre, P = .007); the right occipital lobe (decreased NAA, P = .032 and NAA/Cre, P = .016); and the total cerebrum GM (decreased NAA/Cre, P = .029). No meaningful correlations were obtained between abnormal metabolite values and the neuropsychological measures. CONCLUSIONS: PD is associated with widespread alterations of brain metabolite concentrations, with a primary finding of increased creatine. Higher creatine values in our PD sample may reflect greater neuronal energy expenditure early in the disease process that is compensatory. This is the first whole brain MRS study of PD that has examined metabolite changes across a large fraction of the brain volume, including the cortical mantle.

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