Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS

Charlotte J. Stagg, Steven Knight, Mark Jenkinson, Andrew A Maudsley, Martin R. Turner

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Objective: To demonstrate the sensitivity of a recently developed whole-brain magnetic resonance spectroscopic imaging (MRSI) sequence to cerebral pathology and disability in amyotrophic lateral sclerosis (ALS), and compare with measures derived from diffusion tensor imaging. Methods: Whole-brain MRSI and diffusion tensor imaging were undertaken in 13 patients and 14 age-similar healthy controls. Mean N-acety laspartate (NAA), fractional anisotropy, and mean diffusivity were extracted from the corticospinal tract, compared between groups, and then in relation to disability in the patient group. Results: Significant reductions in NAA were found along the course of the corticospinal tracts on whole-brain MRSI. There were also significant changes in fractional anisotropy (decreased) and mean diffusivity (increased) in the patient group, but only NAA showed a significant relationship with disability (r = 0.65, p = 0.01). Conclusion: Whole-brain MRSI has potential as a quantifiable neuroimaging marker of disability in ALS. It offers renewed hope for a neuroimaging outcome measure with the potential for harmonization across multiple sites in the context of a therapeutic trial.

Original languageEnglish
Pages (from-to)610-615
Number of pages6
JournalNeurology
Volume80
Issue number7
DOIs
StatePublished - Feb 12 2013

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Amyotrophic Lateral Sclerosis
Magnetic Resonance Imaging
Pyramidal Tracts
Diffusion Tensor Imaging
Anisotropy
Brain
Neuroimaging
Outcome Assessment (Health Care)
Pathology
Imaging
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. / Stagg, Charlotte J.; Knight, Steven; Jenkinson, Mark; Maudsley, Andrew A; Turner, Martin R.

In: Neurology, Vol. 80, No. 7, 12.02.2013, p. 610-615.

Research output: Contribution to journalArticle

Stagg, Charlotte J. ; Knight, Steven ; Jenkinson, Mark ; Maudsley, Andrew A ; Turner, Martin R. / Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. In: Neurology. 2013 ; Vol. 80, No. 7. pp. 610-615.
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