White matter structural integrity and trans-cranial Doppler blood flow pulsatility in normal aging

Roman Fleysher, Michael L. Lipton, Olga Noskin, Tatjana Rundek, Richard Lipton, Carol A. Derby

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cerebrovascular diseases underlie many forms of age-related cognitive impairment and the mechanism linking the two is hypothesized to involve adverse changes in white matter (WM) integrity. Despite being systemic, small vessel disease does not uniformly affect WM. We performed voxel-wise analysis of MRI images to examine the association between fractional anisotropy (FA) — a diffusion tensor measure of WM structural integrity — and pulsatility index (PI) — a trans-cranial Doppler ultrasound measure of abnormal arterial flow — in adults over the age of 70 years who were free of stroke and dementia. We demonstrate that the relation of PI to microstructural changes in WM is artery specific and regional. We identified spatial clusters of significant correlations between elevated PI and reduced FA which cannot be explained by aging, supporting a vascular hypothesis of WM injury. These areas are not limited to the vascular territories of the vessels where PI is assessed, suggesting that the linkage between PI and FA is not likely a function of perfusion per se, but is consistent with injury caused by mechanical wave emanating from pulsating vessel walls.

Original languageEnglish (US)
Pages (from-to)97-102
Number of pages6
JournalMagnetic Resonance Imaging
Volume47
DOIs
StatePublished - Apr 1 2018

Fingerprint

Structural integrity
Anisotropy
Blood
Aging of materials
Mechanical waves
Blood Vessels
Magnetic resonance imaging
Tensors
Cerebrovascular Disorders
Doppler Ultrasonography
Ultrasonics
Wounds and Injuries
Dementia
Arteries
Perfusion
Stroke
White Matter

Keywords

  • Aging
  • DTI
  • Fractional anisotropy
  • Pulsatility index
  • TCD
  • White matter structural integrity

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

White matter structural integrity and trans-cranial Doppler blood flow pulsatility in normal aging. / Fleysher, Roman; Lipton, Michael L.; Noskin, Olga; Rundek, Tatjana; Lipton, Richard; Derby, Carol A.

In: Magnetic Resonance Imaging, Vol. 47, 01.04.2018, p. 97-102.

Research output: Contribution to journalArticle

Fleysher, Roman ; Lipton, Michael L. ; Noskin, Olga ; Rundek, Tatjana ; Lipton, Richard ; Derby, Carol A. / White matter structural integrity and trans-cranial Doppler blood flow pulsatility in normal aging. In: Magnetic Resonance Imaging. 2018 ; Vol. 47. pp. 97-102.
@article{a47c11a4f0fe4cd6bcc9b2c45af2d546,
title = "White matter structural integrity and trans-cranial Doppler blood flow pulsatility in normal aging",
abstract = "Cerebrovascular diseases underlie many forms of age-related cognitive impairment and the mechanism linking the two is hypothesized to involve adverse changes in white matter (WM) integrity. Despite being systemic, small vessel disease does not uniformly affect WM. We performed voxel-wise analysis of MRI images to examine the association between fractional anisotropy (FA) — a diffusion tensor measure of WM structural integrity — and pulsatility index (PI) — a trans-cranial Doppler ultrasound measure of abnormal arterial flow — in adults over the age of 70 years who were free of stroke and dementia. We demonstrate that the relation of PI to microstructural changes in WM is artery specific and regional. We identified spatial clusters of significant correlations between elevated PI and reduced FA which cannot be explained by aging, supporting a vascular hypothesis of WM injury. These areas are not limited to the vascular territories of the vessels where PI is assessed, suggesting that the linkage between PI and FA is not likely a function of perfusion per se, but is consistent with injury caused by mechanical wave emanating from pulsating vessel walls.",
keywords = "Aging, DTI, Fractional anisotropy, Pulsatility index, TCD, White matter structural integrity",
author = "Roman Fleysher and Lipton, {Michael L.} and Olga Noskin and Tatjana Rundek and Richard Lipton and Derby, {Carol A.}",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.mri.2017.11.003",
language = "English (US)",
volume = "47",
pages = "97--102",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - White matter structural integrity and trans-cranial Doppler blood flow pulsatility in normal aging

AU - Fleysher, Roman

AU - Lipton, Michael L.

AU - Noskin, Olga

AU - Rundek, Tatjana

AU - Lipton, Richard

AU - Derby, Carol A.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Cerebrovascular diseases underlie many forms of age-related cognitive impairment and the mechanism linking the two is hypothesized to involve adverse changes in white matter (WM) integrity. Despite being systemic, small vessel disease does not uniformly affect WM. We performed voxel-wise analysis of MRI images to examine the association between fractional anisotropy (FA) — a diffusion tensor measure of WM structural integrity — and pulsatility index (PI) — a trans-cranial Doppler ultrasound measure of abnormal arterial flow — in adults over the age of 70 years who were free of stroke and dementia. We demonstrate that the relation of PI to microstructural changes in WM is artery specific and regional. We identified spatial clusters of significant correlations between elevated PI and reduced FA which cannot be explained by aging, supporting a vascular hypothesis of WM injury. These areas are not limited to the vascular territories of the vessels where PI is assessed, suggesting that the linkage between PI and FA is not likely a function of perfusion per se, but is consistent with injury caused by mechanical wave emanating from pulsating vessel walls.

AB - Cerebrovascular diseases underlie many forms of age-related cognitive impairment and the mechanism linking the two is hypothesized to involve adverse changes in white matter (WM) integrity. Despite being systemic, small vessel disease does not uniformly affect WM. We performed voxel-wise analysis of MRI images to examine the association between fractional anisotropy (FA) — a diffusion tensor measure of WM structural integrity — and pulsatility index (PI) — a trans-cranial Doppler ultrasound measure of abnormal arterial flow — in adults over the age of 70 years who were free of stroke and dementia. We demonstrate that the relation of PI to microstructural changes in WM is artery specific and regional. We identified spatial clusters of significant correlations between elevated PI and reduced FA which cannot be explained by aging, supporting a vascular hypothesis of WM injury. These areas are not limited to the vascular territories of the vessels where PI is assessed, suggesting that the linkage between PI and FA is not likely a function of perfusion per se, but is consistent with injury caused by mechanical wave emanating from pulsating vessel walls.

KW - Aging

KW - DTI

KW - Fractional anisotropy

KW - Pulsatility index

KW - TCD

KW - White matter structural integrity

UR - http://www.scopus.com/inward/record.url?scp=85037610142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85037610142&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2017.11.003

DO - 10.1016/j.mri.2017.11.003

M3 - Article

C2 - 29158187

AN - SCOPUS:85037610142

VL - 47

SP - 97

EP - 102

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

ER -