Abstract
The essential need for mitochondrial function has been extensively shown to relate to neuronal health. Neurodegeneration and neurodegeneration-related diseases have been associated with multiple mitochondrial dysfunctions. This review highlights key findings related to commonly studied mitochondrial dysfunctions: imbalance of mitochondrial dynamics, mutations in the mitochondrial genome, excessive reactive oxygen species, and misfolded protein associations/interactions with the mitochondria. Future research in mitochondrial function will help elucidate complex neurodegenerative events while impacting both individual and societal health.
| Original language | English |
|---|---|
| Pages (from-to) | 63-78 |
| Number of pages | 16 |
| Journal | Methods in molecular biology (Clifton, N.J.) |
| Volume | 648 |
| State | Published - Dec 1 2010 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
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Cite this
Pickrell, A. M., & Moraes, C. T. (2010). What role does mitochondrial stress play in neurodegenerative diseases? Methods in molecular biology (Clifton, N.J.), 648, 63-78.