What role does mitochondrial stress play in neurodegenerative diseases?

Alicia Mae Pickrell, Carlos T Moraes

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The essential need for mitochondrial function has been extensively shown to relate to neuronal health. Neurodegeneration and neurodegeneration-related diseases have been associated with multiple mitochondrial dysfunctions. This review highlights key findings related to commonly studied mitochondrial dysfunctions: imbalance of mitochondrial dynamics, mutations in the mitochondrial genome, excessive reactive oxygen species, and misfolded protein associations/interactions with the mitochondria. Future research in mitochondrial function will help elucidate complex neurodegenerative events while impacting both individual and societal health.

Original languageEnglish
Pages (from-to)63-78
Number of pages16
JournalMethods in molecular biology (Clifton, N.J.)
Volume648
StatePublished - Dec 1 2010
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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