What is the role of CCR3 in choroidal neovascularization?

Yiwen Li, Deqiang Huang, Xin Xia, Zhengying Wang, Lingyu Luo, Rong Wen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The "wet" AMD, characterized by the development of choroidal neovacularization (CNV), could result in rapid and severe loss of central vision. The critical role of vascular endothelial growth factor A (VEGF) in CNV development has been clearly demonstrated and clinically VEGF neutralization has become standard care for wet AMD. Recently, CCR3 was reported to play an important role in CNV development and CCR3 targeting was believed to be superior to VEGF targeting for CNV suppression. Our data in the present work show that blocking CCR3 by a small molecule CCR3 antagonist SB 328437 or CCR3-neutralizing antibodies does not inhibit CNV in the Matrigel CNV models of rat and mouse, whereas VEGF-neutralizing antibodies or rapamycin effectively suppresses CNV. These results question the role of CCR3 in CNV development and the therapeutic approach to suppress CNV by CCR3 targeting.

Original languageEnglish (US)
Title of host publicationRetinal Degenerative Diseases
EditorsMatthew LaVail, Robert Anderson, Christian Grimm, John Ash, Joe Hollyfield
Pages279-284
Number of pages6
DOIs
StatePublished - Jan 23 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume723
ISSN (Print)0065-2598

Keywords

  • AMD
  • Angiogenesis
  • CCR3
  • CNV
  • Matrigel
  • Rapamycin
  • SB328437
  • VEGF-A

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Li, Y., Huang, D., Xia, X., Wang, Z., Luo, L., & Wen, R. (2012). What is the role of CCR3 in choroidal neovascularization? In M. LaVail, R. Anderson, C. Grimm, J. Ash, & J. Hollyfield (Eds.), Retinal Degenerative Diseases (pp. 279-284). (Advances in Experimental Medicine and Biology; Vol. 723). https://doi.org/10.1007/978-1-4614-0631-0_36