Abstract
Image-guided tumour ablation is recommended in patients with early-stage hepatocellular carcinoma (HCC) when surgical options are precluded. Radiofrequency ablation (RFA) has shown superior anticancer effect and greater survival benefit with respect to the seminal percutaneous technique, ethanol injection, in meta-analyses of randomised controlled trials, and is currently established as the standard method for local tumour treatment. Novel thermal and non-thermal techniques for tumour ablation seem to have potential to overcome the limitations of RFA and warrant further clinical investigation. The recent addition of molecular targeted drugs with anti-angiogenic and antiproliferative properties to the therapeutic armamentarium for HCC has prompted the design of clinical trials aimed at investigating the synergies between local ablation and systemic treatments. The outcomes of these trials are eagerly awaited, as they have the potential to revolutionize the treatment of HCC.
| Original language | English (US) |
|---|---|
| Title of host publication | Clinical Dilemmas in Primary Liver Cancer |
| Publisher | Wiley-Blackwell |
| Pages | 142-148 |
| Number of pages | 7 |
| ISBN (Print) | 9780470657973 |
| DOIs | |
| State | Published - Nov 29 2011 |
| Externally published | Yes |
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Keywords
- Combination therapy
- Ethanol injection
- Radiofrequency ablation
- Sorafenib
ASJC Scopus subject areas
- Medicine(all)
Cite this
What is the Future of Image-Guided Radiofrequency Ablation for Hepatocellular Carcinoma? / Lencioni, Riccardo.
Clinical Dilemmas in Primary Liver Cancer. Wiley-Blackwell, 2011. p. 142-148.Research output: Chapter in Book/Report/Conference proceeding › Chapter
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TY - CHAP
T1 - What is the Future of Image-Guided Radiofrequency Ablation for Hepatocellular Carcinoma?
AU - Lencioni, Riccardo
PY - 2011/11/29
Y1 - 2011/11/29
N2 - Image-guided tumour ablation is recommended in patients with early-stage hepatocellular carcinoma (HCC) when surgical options are precluded. Radiofrequency ablation (RFA) has shown superior anticancer effect and greater survival benefit with respect to the seminal percutaneous technique, ethanol injection, in meta-analyses of randomised controlled trials, and is currently established as the standard method for local tumour treatment. Novel thermal and non-thermal techniques for tumour ablation seem to have potential to overcome the limitations of RFA and warrant further clinical investigation. The recent addition of molecular targeted drugs with anti-angiogenic and antiproliferative properties to the therapeutic armamentarium for HCC has prompted the design of clinical trials aimed at investigating the synergies between local ablation and systemic treatments. The outcomes of these trials are eagerly awaited, as they have the potential to revolutionize the treatment of HCC.
AB - Image-guided tumour ablation is recommended in patients with early-stage hepatocellular carcinoma (HCC) when surgical options are precluded. Radiofrequency ablation (RFA) has shown superior anticancer effect and greater survival benefit with respect to the seminal percutaneous technique, ethanol injection, in meta-analyses of randomised controlled trials, and is currently established as the standard method for local tumour treatment. Novel thermal and non-thermal techniques for tumour ablation seem to have potential to overcome the limitations of RFA and warrant further clinical investigation. The recent addition of molecular targeted drugs with anti-angiogenic and antiproliferative properties to the therapeutic armamentarium for HCC has prompted the design of clinical trials aimed at investigating the synergies between local ablation and systemic treatments. The outcomes of these trials are eagerly awaited, as they have the potential to revolutionize the treatment of HCC.
KW - Combination therapy
KW - Ethanol injection
KW - Radiofrequency ablation
KW - Sorafenib
UR - http://www.scopus.com/inward/record.url?scp=84886352996&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886352996&partnerID=8YFLogxK
U2 - 10.1002/9781119962205.ch20
DO - 10.1002/9781119962205.ch20
M3 - Chapter
SN - 9780470657973
SP - 142
EP - 148
BT - Clinical Dilemmas in Primary Liver Cancer
PB - Wiley-Blackwell
ER -