What is the biological basis of pattern formation of skin lesions?

Cheng Ming Chuong, Danielle Dhouailly, Stephen Gilmore, Loic Forest, Walter B. Shelley, K. Stenn, Philip Maini, Frederic Michon, S. Parimoo, Sébastien Cadau, Jacques Demongeot, Y. Zheng, Ralf Paus, Rudolf Happle

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Pattern recognition is at the heart of clinical dermatology and dermatopathology. Yet, while every practitioner of the art of dermatological diagnosis recognizes the supreme value of diagnostic cues provided by defined patterns of 'efflorescences', few contemplate on the biological basis of pattern formation in and of skin lesions. Vice versa, developmental and theoretical biologists, who would be best prepared to study skin lesion patterns, are lamentably slow to discover this field as a uniquely instructive testing ground for probing theoretical concepts on pattern generation in the human system. As a result, we have at best scraped the surface of understanding the biological basis of pattern formation of skin lesions, and widely open questions dominate over definitive answer. As a symmetry- breaking force, pattern formation represents one of the most fundamental principles that nature enlists for system organization. Thus, the peculiar and often characteristic arrangements that skin lesions display provide a unique opportunity to reflect upon - and to experimentally dissect - the powerful organizing principles at the crossroads of developmental, skin and theoretical biology, genetics, and clinical dermatology that underlie these - increasingly less enigmatic - phenomena. The current 'Controversies' feature offers a range of different perspectives on how pattern formation of skin lesions can be approached. With this, we hope to encourage more systematic interdisciplinary research efforts geared at unraveling the many unsolved, yet utterly fascinating mysteries of dermatological pattern formation. In short: never a dull pattern!.

Original languageEnglish (US)
Pages (from-to)547-564
Number of pages18
JournalExperimental dermatology
Issue number7
StatePublished - Jul 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology


Dive into the research topics of 'What is the biological basis of pattern formation of skin lesions?'. Together they form a unique fingerprint.

Cite this