TY - JOUR
T1 - What is the biological basis of pattern formation of skin lesions?
AU - Chuong, Cheng Ming
AU - Dhouailly, Danielle
AU - Gilmore, Stephen
AU - Forest, Loic
AU - Shelley, Walter B.
AU - Stenn, K.
AU - Maini, Philip
AU - Michon, Frederic
AU - Parimoo, S.
AU - Cadau, Sébastien
AU - Demongeot, Jacques
AU - Zheng, Y.
AU - Paus, Ralf
AU - Happle, Rudolf
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2006/7
Y1 - 2006/7
N2 - Pattern recognition is at the heart of clinical dermatology and dermatopathology. Yet, while every practitioner of the art of dermatological diagnosis recognizes the supreme value of diagnostic cues provided by defined patterns of 'efflorescences', few contemplate on the biological basis of pattern formation in and of skin lesions. Vice versa, developmental and theoretical biologists, who would be best prepared to study skin lesion patterns, are lamentably slow to discover this field as a uniquely instructive testing ground for probing theoretical concepts on pattern generation in the human system. As a result, we have at best scraped the surface of understanding the biological basis of pattern formation of skin lesions, and widely open questions dominate over definitive answer. As a symmetry- breaking force, pattern formation represents one of the most fundamental principles that nature enlists for system organization. Thus, the peculiar and often characteristic arrangements that skin lesions display provide a unique opportunity to reflect upon - and to experimentally dissect - the powerful organizing principles at the crossroads of developmental, skin and theoretical biology, genetics, and clinical dermatology that underlie these - increasingly less enigmatic - phenomena. The current 'Controversies' feature offers a range of different perspectives on how pattern formation of skin lesions can be approached. With this, we hope to encourage more systematic interdisciplinary research efforts geared at unraveling the many unsolved, yet utterly fascinating mysteries of dermatological pattern formation. In short: never a dull pattern!.
AB - Pattern recognition is at the heart of clinical dermatology and dermatopathology. Yet, while every practitioner of the art of dermatological diagnosis recognizes the supreme value of diagnostic cues provided by defined patterns of 'efflorescences', few contemplate on the biological basis of pattern formation in and of skin lesions. Vice versa, developmental and theoretical biologists, who would be best prepared to study skin lesion patterns, are lamentably slow to discover this field as a uniquely instructive testing ground for probing theoretical concepts on pattern generation in the human system. As a result, we have at best scraped the surface of understanding the biological basis of pattern formation of skin lesions, and widely open questions dominate over definitive answer. As a symmetry- breaking force, pattern formation represents one of the most fundamental principles that nature enlists for system organization. Thus, the peculiar and often characteristic arrangements that skin lesions display provide a unique opportunity to reflect upon - and to experimentally dissect - the powerful organizing principles at the crossroads of developmental, skin and theoretical biology, genetics, and clinical dermatology that underlie these - increasingly less enigmatic - phenomena. The current 'Controversies' feature offers a range of different perspectives on how pattern formation of skin lesions can be approached. With this, we hope to encourage more systematic interdisciplinary research efforts geared at unraveling the many unsolved, yet utterly fascinating mysteries of dermatological pattern formation. In short: never a dull pattern!.
UR - http://www.scopus.com/inward/record.url?scp=33744803223&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33744803223&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0625.2006.00448_1.x
DO - 10.1111/j.1600-0625.2006.00448_1.x
M3 - Article
C2 - 16761964
AN - SCOPUS:33744803223
VL - 15
SP - 547
EP - 564
JO - Experimental Dermatology
JF - Experimental Dermatology
SN - 0906-6705
IS - 7
ER -