What causes Waldenström's macroglobulinemia: Genetic or immune-related factors, or a combination?

Sigurdur Y. Kristinsson, Ola Landgren

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Population-based studies suggest a role for chronic immune stimulation and genetic factors in the causation of lymphoplasmacytic lymphoma (LPL)/Waldenström's macroglobulinemia (WM). In this review we summarize and discuss our current understanding on etiology and pathogenesis of LPL/WM. We also highlight on gaps in the literature and propose future directions for population-based and molecular studies designed to expand our knowledge and uncover biological underpinnings of identified associations. Further, we address clinical implications and provide perspective on the relevance of these data for patient counseling and clinical follow-up.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalClinical Lymphoma, Myeloma and Leukemia
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'What causes Waldenström's macroglobulinemia: Genetic or immune-related factors, or a combination?'. Together they form a unique fingerprint.

Cite this