What causes hidradenitis suppurativa ?—15 years after

Christos C. Zouboulis, Farida Benhadou, Angel S. Byrd, Nisha S. Chandran, Evangelos J. Giamarellos-Bourboulis, Gabriella Fabbrocini, John W. Frew, Hideki Fujita, Marcos A. González-López, Philippe Guillem, Wayne P.F. Gulliver, Iltefat Hamzavi, Yildiz Hayran, Barbara Hórvath, Sophie Hüe, Robert E. Hunger, John R. Ingram, Gregor B.E. Jemec, Qiang Ju, Alexa B. KimballJoslyn S. Kirby, Maria P. Konstantinou, Michelle A. Lowes, Amanda S. MacLeod, Antonio Martorell, Angelo V. Marzano, Łukasz Matusiak, Aude Nassif, Elena Nikiphorou, Georgios Nikolakis, André Nogueira da Costa, Martin M. Okun, Lauren A.V. Orenstein, José Carlos Pascual, Ralf Paus, Benjamin Perin, Errol P. Prens, Till A. Röhn, Andrea Szegedi, Jacek C. Szepietowski, Thrasyvoulos Tzellos, Baoxi Wang, Hessel H. van der Zee

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30–April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote “Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy.” (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as “the only inflammatory skin disease than can be healed”. This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future.

Original languageEnglish (US)
Pages (from-to)1154-1170
Number of pages17
JournalExperimental dermatology
Volume29
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • acne inversa
  • hair follicle
  • hidradenitis suppurativa
  • inflammatory skin diseases
  • pathogenesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology

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