Well-differentiated osteosarcoma of the jaw bones: A clinicopathologic study of 15 cases

Elizabeth G. Demicco, Vikram Deshpande, G. Petur Nielsen, Susan V. Kattapuram, Andrew E. Rosenberg

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.

Original languageEnglish (US)
Pages (from-to)1647-1655
Number of pages9
JournalAmerican Journal of Surgical Pathology
Issue number11
StatePublished - Nov 1 2010
Externally publishedYes


  • jaw bones
  • low grade
  • mandible
  • maxilla
  • well-differentiated osteosarcoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery


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