Well-differentiated osteosarcoma of the jaw bones

A clinicopathologic study of 15 cases

Elizabeth G. Demicco, Vikram Deshpande, G. Petur Nielsen, Susan V. Kattapuram, Andrew Rosenberg

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.

Original languageEnglish
Pages (from-to)1647-1655
Number of pages9
JournalAmerican Journal of Surgical Pathology
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2010
Externally publishedYes

Fingerprint

Osteosarcoma
Jaw
Bone and Bones
Neoplasms
Maxilla
Mandible
Radiotherapy
Neoplasm Metastasis
Recurrence
Therapeutics

Keywords

  • jaw bones
  • low grade
  • mandible
  • maxilla
  • well-differentiated osteosarcoma

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Well-differentiated osteosarcoma of the jaw bones : A clinicopathologic study of 15 cases. / Demicco, Elizabeth G.; Deshpande, Vikram; Nielsen, G. Petur; Kattapuram, Susan V.; Rosenberg, Andrew.

In: American Journal of Surgical Pathology, Vol. 34, No. 11, 01.11.2010, p. 1647-1655.

Research output: Contribution to journalArticle

Demicco, Elizabeth G. ; Deshpande, Vikram ; Nielsen, G. Petur ; Kattapuram, Susan V. ; Rosenberg, Andrew. / Well-differentiated osteosarcoma of the jaw bones : A clinicopathologic study of 15 cases. In: American Journal of Surgical Pathology. 2010 ; Vol. 34, No. 11. pp. 1647-1655.
@article{185769d202e548e3bef8ff8987af6421,
title = "Well-differentiated osteosarcoma of the jaw bones: A clinicopathologic study of 15 cases",
abstract = "Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.",
keywords = "jaw bones, low grade, mandible, maxilla, well-differentiated osteosarcoma",
author = "Demicco, {Elizabeth G.} and Vikram Deshpande and Nielsen, {G. Petur} and Kattapuram, {Susan V.} and Andrew Rosenberg",
year = "2010",
month = "11",
day = "1",
doi = "10.1097/PAS.0b013e3181f7dac6",
language = "English",
volume = "34",
pages = "1647--1655",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Well-differentiated osteosarcoma of the jaw bones

T2 - A clinicopathologic study of 15 cases

AU - Demicco, Elizabeth G.

AU - Deshpande, Vikram

AU - Nielsen, G. Petur

AU - Kattapuram, Susan V.

AU - Rosenberg, Andrew

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.

AB - Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.

KW - jaw bones

KW - low grade

KW - mandible

KW - maxilla

KW - well-differentiated osteosarcoma

UR - http://www.scopus.com/inward/record.url?scp=78049527727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049527727&partnerID=8YFLogxK

U2 - 10.1097/PAS.0b013e3181f7dac6

DO - 10.1097/PAS.0b013e3181f7dac6

M3 - Article

VL - 34

SP - 1647

EP - 1655

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 11

ER -