Abstract
Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.
| Original language | English |
|---|---|
| Pages (from-to) | 1647-1655 |
| Number of pages | 9 |
| Journal | American Journal of Surgical Pathology |
| Volume | 34 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2010 |
| Externally published | Yes |
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Keywords
- jaw bones
- low grade
- mandible
- maxilla
- well-differentiated osteosarcoma
ASJC Scopus subject areas
- Anatomy
- Pathology and Forensic Medicine
- Surgery
Cite this
Well-differentiated osteosarcoma of the jaw bones : A clinicopathologic study of 15 cases. / Demicco, Elizabeth G.; Deshpande, Vikram; Nielsen, G. Petur; Kattapuram, Susan V.; Rosenberg, Andrew.
In: American Journal of Surgical Pathology, Vol. 34, No. 11, 01.11.2010, p. 1647-1655.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Well-differentiated osteosarcoma of the jaw bones
T2 - A clinicopathologic study of 15 cases
AU - Demicco, Elizabeth G.
AU - Deshpande, Vikram
AU - Nielsen, G. Petur
AU - Kattapuram, Susan V.
AU - Rosenberg, Andrew
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.
AB - Well-differentiated osteosarcoma of the jaw bones is rare, and is often confused with a variety of benign fibroosseous lesions. To better understand its clinicopathologic features, we reviewed our experience with 15 cases. The patients included 7 males and 8 females (age range 14 to 66y; mean 42.8y). Six of the tumors arose in the mandible, and 9 in the maxilla. Microscopically, the tumors were infiltrative, relatively hypocellular, and consisted of monomorphic, minimally atypical spindle cells that were usually arranged in fascicles. The tumor cells were intimately related to the surfaces of elongated trabeculae of neoplastic woven bone that lacked osteoblastic rimming. Nine patients were treated with wide excision, 2 patients with marginal excision, and 2 patients with excision and radiation therapy. After definitive therapy, there were no reports of recurrence or metastasis over an average follow-up of 34 months (range 1 to 80 mo). Well-differentiated gnathic osteosarcoma is a low-grade malignancy that may be successfully treated with wide local excision. The prognosis in our series was excellent.
KW - jaw bones
KW - low grade
KW - mandible
KW - maxilla
KW - well-differentiated osteosarcoma
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UR - http://www.scopus.com/inward/citedby.url?scp=78049527727&partnerID=8YFLogxK
U2 - 10.1097/PAS.0b013e3181f7dac6
DO - 10.1097/PAS.0b013e3181f7dac6
M3 - Article
VL - 34
SP - 1647
EP - 1655
JO - American Journal of Surgical Pathology
JF - American Journal of Surgical Pathology
SN - 0147-5185
IS - 11
ER -