Wegener's granulomatosis

Prospective clinical and therapeutic experience with 85 patients for 21 years

A. S. Fauci, B. F. Haynes, P. Katz, S. M. Wolff

Research output: Contribution to journalArticle

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Abstract

Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health. Patients were treated with a protocol consisting of cyclophosphamide, 2 mg/kg body weight·d, together with prednisone, 1 mg/kg bodyweight ·d, followed by conversion of the prednisone to an alternate-day regimen. Complete remissions were achieved in 79 of 85 patients (93%). The mean duration of remission for living patients was 48.2 (± 3.6) months. Twenty-three patients are off all therapy for a mean duration of 35.3 (± 6.3) months without therapy. This study provides a prospective experience with Wegener's granulomatosis and shows that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.

Original languageEnglish
Pages (from-to)76-85
Number of pages10
JournalAnnals of Internal Medicine
Volume98
Issue number1
StatePublished - Jan 1 1983
Externally publishedYes

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Granulomatosis with Polyangiitis
Prednisone
Cyclophosphamide
Therapeutics
National Institutes of Health (U.S.)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wegener's granulomatosis : Prospective clinical and therapeutic experience with 85 patients for 21 years. / Fauci, A. S.; Haynes, B. F.; Katz, P.; Wolff, S. M.

In: Annals of Internal Medicine, Vol. 98, No. 1, 01.01.1983, p. 76-85.

Research output: Contribution to journalArticle

Fauci, A. S. ; Haynes, B. F. ; Katz, P. ; Wolff, S. M. / Wegener's granulomatosis : Prospective clinical and therapeutic experience with 85 patients for 21 years. In: Annals of Internal Medicine. 1983 ; Vol. 98, No. 1. pp. 76-85.
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