Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients for 21 years

A. S. Fauci, B. F. Haynes, P. Katz, S. M. Wolff

Research output: Contribution to journalReview article

1525 Scopus citations

Abstract

Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health. Patients were treated with a protocol consisting of cyclophosphamide, 2 mg/kg body weight·d, together with prednisone, 1 mg/kg bodyweight ·d, followed by conversion of the prednisone to an alternate-day regimen. Complete remissions were achieved in 79 of 85 patients (93%). The mean duration of remission for living patients was 48.2 (± 3.6) months. Twenty-three patients are off all therapy for a mean duration of 35.3 (± 6.3) months without therapy. This study provides a prospective experience with Wegener's granulomatosis and shows that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.

Original languageEnglish (US)
Pages (from-to)76-85
Number of pages10
JournalAnnals of internal medicine
Volume98
Issue number1
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Internal Medicine

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