Water-borne, in situ crosslinked biomaterials from phase-segregated precursors

Brent Vernon, Nicola Tirelli, Thomas Bächi, David Haldimann, Jeffrey A. Hubbell

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

A novel process for the preparation of waterborne biomaterials for hard tissue repair from injectable precursors is described, where the precursors form crosslinked materials in situ under physiological conditions. The precursors react by means of a Michael-type addition reaction that makes use of addition donors such as pentaerythritol tetrakis 3′-mercaptopropionate (QT) and addition acceptors such as poly(ethylene glycol) diacrylate 570 MW (PEGDA), pentaerythritol triacrylate (TA), and poly(propylene glycol) diacrylate 900 MW (PPODA). These crosslinked materials (at 75 wt% solid), prepared from water dispersions or reverse emulsions, showed ultimate strengths in compression of 1.8 ± 0.2 and 6.7 ± 0.5 MPa and ultimate deformations of 35 ± 2± and 37 ± 2%, respectively. Scanning electron microscopy (SEM) shows that the morphology of the precursors templated the morphology of the final materials. The current study indicates that it is possible to obtain injectable high-modulus materials that have appropriate mechanical properties and gelation kinetics for tissue augmentation and stabilization applications such as mechanical stabilization of the intervertebral disc annulus.

Original languageEnglish (US)
Pages (from-to)447-456
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume64
Issue number3
StatePublished - Mar 1 2003

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Keywords

  • Emulsions
  • In situ crosslinking
  • Injectable biomaterials
  • Intervertebral disc
  • Michael-type reaction
  • SEM

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Vernon, B., Tirelli, N., Bächi, T., Haldimann, D., & Hubbell, J. A. (2003). Water-borne, in situ crosslinked biomaterials from phase-segregated precursors. Journal of Biomedical Materials Research - Part A, 64(3), 447-456.