TY - JOUR
T1 - Warfarin and herbal products interaction causing prosthetic aortic valve thrombosis presenting as acute myocardial infarction
AU - Mendoza, Cesar E.
AU - Ferreira, Alexandre C.
AU - De Marchena, Eduardo
PY - 2004/1/1
Y1 - 2004/1/1
N2 - Myocardial infarction (MI) due to coronary artery embolization is a rare and potentially lethal compli-cation of prosthetic heart valve thrombosis. A 58-year-old man in whom the aortic valve was replaced with a bileaflet mechanical valve presented with an acute anterior MI. Valvular dysfunction was detected by physical examination, and confirmed by two-dimensional echocardiography and cinefluoroscopy. Coronary angiography disclosed embolization of the left anterior descending artery. Thrombotic encroach-ment of one of the prosthetic valve leaflets was found at reoperation. Failure to achieve adequate anticoagulation was likely due to an interaction between warfarin and herbal products. These find-ings have significant implications regarding the diagnosis and treatment of acute MI in patients with left-sided prosthetic heart valves, and emphasizes the importance of appropriate anticoagulation in this setting.
AB - Myocardial infarction (MI) due to coronary artery embolization is a rare and potentially lethal compli-cation of prosthetic heart valve thrombosis. A 58-year-old man in whom the aortic valve was replaced with a bileaflet mechanical valve presented with an acute anterior MI. Valvular dysfunction was detected by physical examination, and confirmed by two-dimensional echocardiography and cinefluoroscopy. Coronary angiography disclosed embolization of the left anterior descending artery. Thrombotic encroach-ment of one of the prosthetic valve leaflets was found at reoperation. Failure to achieve adequate anticoagulation was likely due to an interaction between warfarin and herbal products. These find-ings have significant implications regarding the diagnosis and treatment of acute MI in patients with left-sided prosthetic heart valves, and emphasizes the importance of appropriate anticoagulation in this setting.
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M3 - Article
C2 - 14765834
AN - SCOPUS:4344566449
VL - 13
SP - 22
EP - 24
JO - Journal of Heart Valve Disease
JF - Journal of Heart Valve Disease
SN - 0966-8519
IS - 1
ER -