TY - JOUR
T1 - Waist circumference but not body mass index predicts long-term mortality in elderly subjects with chronic heart failure
AU - Testa, Gianluca
AU - Cacciatore, Francesco
AU - Galizia, Gianluigi
AU - Della-Morte, David
AU - Mazzella, Francesca
AU - Langellotto, Assunta
AU - Russo, Salvatore
AU - Gargiulo, Gaetano
AU - De Santis, Domenico
AU - Ferrara, Nicola
AU - Rengo, Franco
AU - Abete, Pasquale
N1 - Copyright:
Copyright 2010 Elsevier B.V., All rights reserved.
PY - 2010/8
Y1 - 2010/8
N2 - Objectives: To examine whether waist circumference (WC) and body-mass index (BMI) can predict long-term mortality in elderly subjects with and without chronic heart failure (CHF). Design: Longitudinal evaluation with a 12-year follow-up. Setting: Campania, a region of southern Italy. Participants: One thousand three hundred thirty-two subjects aged 65 and older selected from the electoral rolls of Campania. Measurements: The relationship between WC or BMI and mortality during a 12-year follow-up in 125 subjects with and 1,143 subjects without CHF. Results: Mortality increased as WC increased in elderly subjects without CHF (from 47.8% to 56.7%, P=.01), and the increase was even greater in patients with CHF (from 58.1% to 82.0%, P=.01). In contrast, mortality decreased as BMI increased in elderly subjects without CHF (from 53.8% to 46.1%, P0 =.046) but not in those with CHF. According to Cox regression analysis, BMI protected against long-term mortality in the absence but not in the presence of CHF. In the absence of CHF, WC was associated with a 2% increased risk of long-term mortality for each 1-cm greater WC (Hazard Ratio (HR)=1.02, 95% confidence interval (CI)=1.01-1.03; P<.001), versus 5% increased in the presence of CHF (HR=1.06, 95% CI=1.02-1.10; P<.001). Conclusion: WC, but not BMI, is predictive of long-term mortality in elderly individuals with CHF and to a lesser extent in those without CHF.
AB - Objectives: To examine whether waist circumference (WC) and body-mass index (BMI) can predict long-term mortality in elderly subjects with and without chronic heart failure (CHF). Design: Longitudinal evaluation with a 12-year follow-up. Setting: Campania, a region of southern Italy. Participants: One thousand three hundred thirty-two subjects aged 65 and older selected from the electoral rolls of Campania. Measurements: The relationship between WC or BMI and mortality during a 12-year follow-up in 125 subjects with and 1,143 subjects without CHF. Results: Mortality increased as WC increased in elderly subjects without CHF (from 47.8% to 56.7%, P=.01), and the increase was even greater in patients with CHF (from 58.1% to 82.0%, P=.01). In contrast, mortality decreased as BMI increased in elderly subjects without CHF (from 53.8% to 46.1%, P0 =.046) but not in those with CHF. According to Cox regression analysis, BMI protected against long-term mortality in the absence but not in the presence of CHF. In the absence of CHF, WC was associated with a 2% increased risk of long-term mortality for each 1-cm greater WC (Hazard Ratio (HR)=1.02, 95% confidence interval (CI)=1.01-1.03; P<.001), versus 5% increased in the presence of CHF (HR=1.06, 95% CI=1.02-1.10; P<.001). Conclusion: WC, but not BMI, is predictive of long-term mortality in elderly individuals with CHF and to a lesser extent in those without CHF.
KW - body mass index
KW - chronic heart failure
KW - mortality
KW - waist circumference
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U2 - 10.1111/j.1532-5415.2010.02979.x
DO - 10.1111/j.1532-5415.2010.02979.x
M3 - Article
C2 - 20670379
AN - SCOPUS:77955262332
VL - 58
SP - 1433
EP - 1440
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 8
ER -