Waist circumference but not body mass index predicts long-term mortality in elderly subjects with chronic heart failure

Gianluca Testa, Francesco Cacciatore, Gianluigi Galizia, David Della-Morte, Francesca Mazzella, Assunta Langellotto, Salvatore Russo, Gaetano Gargiulo, Domenico De Santis, Nicola Ferrara, Franco Rengo, Pasquale Abete

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Abstract

Objectives: To examine whether waist circumference (WC) and body-mass index (BMI) can predict long-term mortality in elderly subjects with and without chronic heart failure (CHF). Design: Longitudinal evaluation with a 12-year follow-up. Setting: Campania, a region of southern Italy. Participants: One thousand three hundred thirty-two subjects aged 65 and older selected from the electoral rolls of Campania. Measurements: The relationship between WC or BMI and mortality during a 12-year follow-up in 125 subjects with and 1,143 subjects without CHF. Results: Mortality increased as WC increased in elderly subjects without CHF (from 47.8% to 56.7%, P=.01), and the increase was even greater in patients with CHF (from 58.1% to 82.0%, P=.01). In contrast, mortality decreased as BMI increased in elderly subjects without CHF (from 53.8% to 46.1%, P0 =.046) but not in those with CHF. According to Cox regression analysis, BMI protected against long-term mortality in the absence but not in the presence of CHF. In the absence of CHF, WC was associated with a 2% increased risk of long-term mortality for each 1-cm greater WC (Hazard Ratio (HR)=1.02, 95% confidence interval (CI)=1.01-1.03; P<.001), versus 5% increased in the presence of CHF (HR=1.06, 95% CI=1.02-1.10; P<.001). Conclusion: WC, but not BMI, is predictive of long-term mortality in elderly individuals with CHF and to a lesser extent in those without CHF.

Original languageEnglish (US)
Pages (from-to)1433-1440
Number of pages8
JournalJournal of the American Geriatrics Society
Volume58
Issue number8
DOIs
StatePublished - Aug 1 2010

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Keywords

  • body mass index
  • chronic heart failure
  • mortality
  • waist circumference

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Testa, G., Cacciatore, F., Galizia, G., Della-Morte, D., Mazzella, F., Langellotto, A., Russo, S., Gargiulo, G., De Santis, D., Ferrara, N., Rengo, F., & Abete, P. (2010). Waist circumference but not body mass index predicts long-term mortality in elderly subjects with chronic heart failure. Journal of the American Geriatrics Society, 58(8), 1433-1440. https://doi.org/10.1111/j.1532-5415.2010.02979.x