Vulvar Paget's disease

Is immunocytochemistry helpful in assessing the surgical margins?

P. Ganjei, K. A. Giraldo, B. Lampe, Mehrdad Nadji

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

From January 1977 to December 1988, 19 patients with biopsy-proven Paget's disease of the vulva underwent simple or radical vulvectomy at the University of Miami/Jackson Memorial Medical Center. All vulvectomy specimens were evaluated immunocytochemically for the expression of carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA) and low-molecular-weight keratins 8 and 18 (LMK), both in areas containing neoplastic cells and in histologically negative surgical margins. Neoplastic Paget's cells stained positively for CEA in all cases; they were positive for EMA and LMK in 18 and 17 cases, respectively. In all eight cases with underlying in situ or invasive carcinomas, CEA, EMA and LMK were localized in the underlying tumors as well. None of the histologically proven negative margins reacted for CEA, EMA or LMK on immunocytochemistry. CEA appears to be a valuable immunocytochemical marker for extramammary Paget's disease; EMA and LMK are also expressed by the majority of such cases. None of these markers, however, is of added value in identifying Paget's cells in surgical margins if those margins appear negative on routine hematoxylin-and-eosin staining.

Original languageEnglish
Pages (from-to)1002-1004
Number of pages3
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume35
Issue number11
StatePublished - Dec 1 1990

Fingerprint

Vulvar Diseases
Mucin-1
Carcinoembryonic Antigen
Immunohistochemistry
Extramammary Paget's Disease
Keratin-8
Keratin-18
Vulva
Hematoxylin
Eosine Yellowish-(YS)
Molecular Weight
Margins of Excision
Staining and Labeling
Carcinoma
Biopsy
Neoplasms

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Vulvar Paget's disease : Is immunocytochemistry helpful in assessing the surgical margins? / Ganjei, P.; Giraldo, K. A.; Lampe, B.; Nadji, Mehrdad.

In: Journal of Reproductive Medicine for the Obstetrician and Gynecologist, Vol. 35, No. 11, 01.12.1990, p. 1002-1004.

Research output: Contribution to journalArticle

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