Abstract
Consistent elevations of plasma von Willebrand factor antigen were observed in otherwise healthy elderly patients with Kaposi's sarcoma. The elevations were predominantly of the endothelial cell-derived antigen, as opposed to the factor VIII procoagulant, with resultant elevations in the antigen/procoagulant ratios. Lesser elevations were seen in a group of age-matched control subjects who did not have Kaposi's sarcoma or intercurrent illness. The greater elevations in plasma von Willebrand factor antigen therefore appear to be the direct consequence of the presence of Kaposi's sarcoma cells. Our findings also suggest that there is a direct relationship between tumor load and degree of von Willebrand factor antigen elevation.
| Original language | English |
|---|---|
| Pages (from-to) | 1214-1217 |
| Number of pages | 4 |
| Journal | Journal of the American Academy of Dermatology |
| Volume | 15 |
| Issue number | 6 |
| State | Published - Dec 1 1986 |
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ASJC Scopus subject areas
- Dermatology
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Von Willebrand factor antigen levels in Kaposi's sarcoma. / Penneys, N. S.; Kott-Blumenkranz, R.; Civantos, Francisco; Kent, J.
In: Journal of the American Academy of Dermatology, Vol. 15, No. 6, 01.12.1986, p. 1214-1217.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Von Willebrand factor antigen levels in Kaposi's sarcoma
AU - Penneys, N. S.
AU - Kott-Blumenkranz, R.
AU - Civantos, Francisco
AU - Kent, J.
PY - 1986/12/1
Y1 - 1986/12/1
N2 - Consistent elevations of plasma von Willebrand factor antigen were observed in otherwise healthy elderly patients with Kaposi's sarcoma. The elevations were predominantly of the endothelial cell-derived antigen, as opposed to the factor VIII procoagulant, with resultant elevations in the antigen/procoagulant ratios. Lesser elevations were seen in a group of age-matched control subjects who did not have Kaposi's sarcoma or intercurrent illness. The greater elevations in plasma von Willebrand factor antigen therefore appear to be the direct consequence of the presence of Kaposi's sarcoma cells. Our findings also suggest that there is a direct relationship between tumor load and degree of von Willebrand factor antigen elevation.
AB - Consistent elevations of plasma von Willebrand factor antigen were observed in otherwise healthy elderly patients with Kaposi's sarcoma. The elevations were predominantly of the endothelial cell-derived antigen, as opposed to the factor VIII procoagulant, with resultant elevations in the antigen/procoagulant ratios. Lesser elevations were seen in a group of age-matched control subjects who did not have Kaposi's sarcoma or intercurrent illness. The greater elevations in plasma von Willebrand factor antigen therefore appear to be the direct consequence of the presence of Kaposi's sarcoma cells. Our findings also suggest that there is a direct relationship between tumor load and degree of von Willebrand factor antigen elevation.
UR - http://www.scopus.com/inward/record.url?scp=0022977971&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022977971&partnerID=8YFLogxK
M3 - Article
C2 - 3100582
AN - SCOPUS:0022977971
VL - 15
SP - 1214
EP - 1217
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
SN - 0190-9622
IS - 6
ER -