Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice

Olujimi A. Ajijola, Chunming Dong, Edward E. Herderick, Qi Ma, Pascal Goldschmidt-Clermont, Zhen Yan

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Long-term exercise is associated with reduced atherosclerotic burden, inflammation, and enhanced endothelial progenitor cell (EPC) levels in mice. Infusion of progenitor cells in mice decreases atherosclerosis and suppresses inflammation. The aim of this study was to determine whether exercise-induced enhancement of EPCs is associated with reduced atherosclerosis and inflammation. To study this, 20-week old ApoE-/- mice with advanced atherosclerotic lesions (n = 12/group) were randomized to voluntary running or no running for 8 weeks. Exercise led to a potent suppression of elevated circulating proinflammatory cytokines without significant reduction of atherosclerotic lesions. When repeated in ApoE-/- mice with early atherosclerotic disease, exercise led to a 62% (p = 0.017) reduction in lesion thickness (intima-to-media ratio) at the aortic root. Interestingly, BM-EPC levels were significantly elevated under proinflammatory conditions seen in ApoE-/- mice and decreased in response to exercise, independent of the degree of atherosclerosis. Under early atherosclerotic conditions, long-term exercise reduces atherosclerotic plaque burden and is associated with reduced systemic inflammation. Elevated BM-EPCs seen in atherosclerotic conditions may be a marker of generalized vascular inflammation or injury, and decrease in response to exercise, along with other markers of inflammation.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalAntioxidants and Redox Signaling
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Endothelial cells
Apolipoproteins E
Running
Bone Marrow Cells
Bone
Cytokines
Inflammation
Atherosclerosis
Atherosclerotic Plaques
Blood Vessels
Endothelial Progenitor Cells
Stem Cells
erucylphosphocholine
Wounds and Injuries

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Physiology
  • Clinical Biochemistry

Cite this

Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice. / Ajijola, Olujimi A.; Dong, Chunming; Herderick, Edward E.; Ma, Qi; Goldschmidt-Clermont, Pascal; Yan, Zhen.

In: Antioxidants and Redox Signaling, Vol. 11, No. 1, 01.01.2009, p. 15-23.

Research output: Contribution to journalArticle

Ajijola, Olujimi A. ; Dong, Chunming ; Herderick, Edward E. ; Ma, Qi ; Goldschmidt-Clermont, Pascal ; Yan, Zhen. / Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice. In: Antioxidants and Redox Signaling. 2009 ; Vol. 11, No. 1. pp. 15-23.
@article{a6c2fcc402ce41a6a9bb2f623b5b1747,
title = "Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice",
abstract = "Long-term exercise is associated with reduced atherosclerotic burden, inflammation, and enhanced endothelial progenitor cell (EPC) levels in mice. Infusion of progenitor cells in mice decreases atherosclerosis and suppresses inflammation. The aim of this study was to determine whether exercise-induced enhancement of EPCs is associated with reduced atherosclerosis and inflammation. To study this, 20-week old ApoE-/- mice with advanced atherosclerotic lesions (n = 12/group) were randomized to voluntary running or no running for 8 weeks. Exercise led to a potent suppression of elevated circulating proinflammatory cytokines without significant reduction of atherosclerotic lesions. When repeated in ApoE-/- mice with early atherosclerotic disease, exercise led to a 62{\%} (p = 0.017) reduction in lesion thickness (intima-to-media ratio) at the aortic root. Interestingly, BM-EPC levels were significantly elevated under proinflammatory conditions seen in ApoE-/- mice and decreased in response to exercise, independent of the degree of atherosclerosis. Under early atherosclerotic conditions, long-term exercise reduces atherosclerotic plaque burden and is associated with reduced systemic inflammation. Elevated BM-EPCs seen in atherosclerotic conditions may be a marker of generalized vascular inflammation or injury, and decrease in response to exercise, along with other markers of inflammation.",
author = "Ajijola, {Olujimi A.} and Chunming Dong and Herderick, {Edward E.} and Qi Ma and Pascal Goldschmidt-Clermont and Zhen Yan",
year = "2009",
month = "1",
day = "1",
doi = "10.1089/ars.2008.2092",
language = "English",
volume = "11",
pages = "15--23",
journal = "Antioxidants and Redox Signaling",
issn = "1523-0864",
publisher = "Mary Ann Liebert Inc.",
number = "1",

}

TY - JOUR

T1 - Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice

AU - Ajijola, Olujimi A.

AU - Dong, Chunming

AU - Herderick, Edward E.

AU - Ma, Qi

AU - Goldschmidt-Clermont, Pascal

AU - Yan, Zhen

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Long-term exercise is associated with reduced atherosclerotic burden, inflammation, and enhanced endothelial progenitor cell (EPC) levels in mice. Infusion of progenitor cells in mice decreases atherosclerosis and suppresses inflammation. The aim of this study was to determine whether exercise-induced enhancement of EPCs is associated with reduced atherosclerosis and inflammation. To study this, 20-week old ApoE-/- mice with advanced atherosclerotic lesions (n = 12/group) were randomized to voluntary running or no running for 8 weeks. Exercise led to a potent suppression of elevated circulating proinflammatory cytokines without significant reduction of atherosclerotic lesions. When repeated in ApoE-/- mice with early atherosclerotic disease, exercise led to a 62% (p = 0.017) reduction in lesion thickness (intima-to-media ratio) at the aortic root. Interestingly, BM-EPC levels were significantly elevated under proinflammatory conditions seen in ApoE-/- mice and decreased in response to exercise, independent of the degree of atherosclerosis. Under early atherosclerotic conditions, long-term exercise reduces atherosclerotic plaque burden and is associated with reduced systemic inflammation. Elevated BM-EPCs seen in atherosclerotic conditions may be a marker of generalized vascular inflammation or injury, and decrease in response to exercise, along with other markers of inflammation.

AB - Long-term exercise is associated with reduced atherosclerotic burden, inflammation, and enhanced endothelial progenitor cell (EPC) levels in mice. Infusion of progenitor cells in mice decreases atherosclerosis and suppresses inflammation. The aim of this study was to determine whether exercise-induced enhancement of EPCs is associated with reduced atherosclerosis and inflammation. To study this, 20-week old ApoE-/- mice with advanced atherosclerotic lesions (n = 12/group) were randomized to voluntary running or no running for 8 weeks. Exercise led to a potent suppression of elevated circulating proinflammatory cytokines without significant reduction of atherosclerotic lesions. When repeated in ApoE-/- mice with early atherosclerotic disease, exercise led to a 62% (p = 0.017) reduction in lesion thickness (intima-to-media ratio) at the aortic root. Interestingly, BM-EPC levels were significantly elevated under proinflammatory conditions seen in ApoE-/- mice and decreased in response to exercise, independent of the degree of atherosclerosis. Under early atherosclerotic conditions, long-term exercise reduces atherosclerotic plaque burden and is associated with reduced systemic inflammation. Elevated BM-EPCs seen in atherosclerotic conditions may be a marker of generalized vascular inflammation or injury, and decrease in response to exercise, along with other markers of inflammation.

UR - http://www.scopus.com/inward/record.url?scp=55249111303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=55249111303&partnerID=8YFLogxK

U2 - 10.1089/ars.2008.2092

DO - 10.1089/ars.2008.2092

M3 - Article

C2 - 18837653

AN - SCOPUS:55249111303

VL - 11

SP - 15

EP - 23

JO - Antioxidants and Redox Signaling

JF - Antioxidants and Redox Signaling

SN - 1523-0864

IS - 1

ER -