TY - JOUR
T1 - Volumetric and visual rating of magnetic resonance imaging scans in the diagnosis of amnestic mild cognitive impairment and Alzheimer's disease
AU - Shen, Qian
AU - Loewenstein, David A.
AU - Potter, Elizabeth
AU - Zhao, Weizhao
AU - Appel, Jason
AU - Greig, Maria T.
AU - Raj, Ashok
AU - Acevedo, Amarilis
AU - Schofield, Elizabeth
AU - Barker, Warren
AU - Wu, Yougui
AU - Potter, Huntington
AU - Duara, Ranjan
N1 - Funding Information:
Statistical analysis was performed by David A. Loewenstein, Ph.D., University of Miami. This research was supported by the National Institute of Aging , NIH 5R01AG020094-03 and NIH 1P50AG025711-03 , & Byrd Alzheimer Center and Research Institute grants.
PY - 2011/7
Y1 - 2011/7
N2 - Background: In the diagnosis of Alzheimer's disease (AD), structural magnetic resonance imaging (MRI) scans have been used primarily to exclude non-Alzheimer's causes of dementia. However, the pattern and the extent of medial temporal atrophy on structural MRI scans, which correlate strongly with the pathological severity of AD, can be used to support the diagnosis of a degenerative dementia, especially AD, even in its early predementia stage. Methods: Elderly subjects (n = 224) were diagnosed with either no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), or AD. Hippocampal and hemispheric gray matter volumes were measured on structural MRI scans, and a new visual rating system was used to score the severity of medial temporal atrophy (VRS-MTA) of the hippocampus (HPC), entorhinal cortex, and perirhinal cortex on a coronal image intersecting the mammillary bodies. Results: Although both VRS-MTA scores and HPC volumes distinguished between subjects with NCI, aMCI, and AD, subjects with aMCI and NCI could be better distinguished using right VRS-MTA scores, in comparison with right HPC volumes. VRS-MTA scores were more highly correlated with episodic memory and Clinical Dementia Rating scores. A combination of left sided VRS-MTA scores and left sided hippocampal volume was the most predictive measure of diagnostic classification. Conclusion: VRS-MTA is a clinically convenient method or distinguishing aMCI or AD from NCI. As compared with volumetric measures, it provides better discriminatory power and correlates more strongly with memory and functional scores.
AB - Background: In the diagnosis of Alzheimer's disease (AD), structural magnetic resonance imaging (MRI) scans have been used primarily to exclude non-Alzheimer's causes of dementia. However, the pattern and the extent of medial temporal atrophy on structural MRI scans, which correlate strongly with the pathological severity of AD, can be used to support the diagnosis of a degenerative dementia, especially AD, even in its early predementia stage. Methods: Elderly subjects (n = 224) were diagnosed with either no cognitive impairment (NCI), amnestic mild cognitive impairment (aMCI), or AD. Hippocampal and hemispheric gray matter volumes were measured on structural MRI scans, and a new visual rating system was used to score the severity of medial temporal atrophy (VRS-MTA) of the hippocampus (HPC), entorhinal cortex, and perirhinal cortex on a coronal image intersecting the mammillary bodies. Results: Although both VRS-MTA scores and HPC volumes distinguished between subjects with NCI, aMCI, and AD, subjects with aMCI and NCI could be better distinguished using right VRS-MTA scores, in comparison with right HPC volumes. VRS-MTA scores were more highly correlated with episodic memory and Clinical Dementia Rating scores. A combination of left sided VRS-MTA scores and left sided hippocampal volume was the most predictive measure of diagnostic classification. Conclusion: VRS-MTA is a clinically convenient method or distinguishing aMCI or AD from NCI. As compared with volumetric measures, it provides better discriminatory power and correlates more strongly with memory and functional scores.
KW - Alzheimer disease
KW - Brain MRI
KW - Cognitive impairment
KW - Dementia
KW - Diagnosis
KW - Medial temporal atrophy
KW - Neuropsychological tests
KW - Visual rating
KW - Volumetric analysis
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U2 - 10.1016/j.jalz.2010.07.002
DO - 10.1016/j.jalz.2010.07.002
M3 - Article
C2 - 21784342
AN - SCOPUS:79960812353
VL - 7
SP - e101-e108
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
IS - 4
ER -