Volume Guarantee Ventilation: Effect on Preterm Infants with Frequent Hypoxemia Episodes

Deepak Jain, Nelson R Claure, Carmen D'Ugard, Jose Bello, Eduardo Bancalari

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Preterm infants on mechanical ventilation have spontaneous hypoxemia episodes (HE) triggered by decreases in lung volume and tidal volume (VT). Volume guarantee (VG) is a mode where the ventilator peak pressure is adjusted to keep the exhaled VT at a target level. The effect of VG on HE under routine clinical conditions has not been fully evaluated. Objective: To evaluate the effect of VG on HE in preterm infants in comparison to pressure control (PC) ventilation under routine clinical conditions. Methods: Twenty-four mechanically ventilated preterm infants with ≥4 HE of arterial oxygen saturation (SpO2) 2 2 2 2) was lower during VG compared to PC. Conclusion: The use of VG during routine clinical conditions resulted in a modest reduction in the duration of HE (SpO2 2 compared to PC. The use of VG did not reduce the more severe HE.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
StateAccepted/In press - Apr 19 2016


  • Arterial oxygen saturation#
  • Intermittent hypoxemia
  • Premature infant
  • Volume-targeted ventilation

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health


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