Volume Guarantee Ventilation: Effect on Preterm Infants with Frequent Hypoxemia Episodes

Deepak Jain; Nelson R Claure; Carmen D'Ugard; Jose Bello; Eduardo Bancalari

doi:10.1159/000444844

Volume Guarantee Ventilation: Effect on Preterm Infants with Frequent Hypoxemia Episodes

Deepak Jain, Nelson R Claure, Carmen D'Ugard, Jose Bello, Eduardo Bancalari

Pediatrics

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Preterm infants on mechanical ventilation have spontaneous hypoxemia episodes (HE) triggered by decreases in lung volume and tidal volume (V_T). Volume guarantee (VG) is a mode where the ventilator peak pressure is adjusted to keep the exhaled V_T at a target level. The effect of VG on HE under routine clinical conditions has not been fully evaluated. Objective: To evaluate the effect of VG on HE in preterm infants in comparison to pressure control (PC) ventilation under routine clinical conditions. Methods: Twenty-four mechanically ventilated preterm infants with ≥4 HE of arterial oxygen saturation (SpO₂) 2 2 2 2) was lower during VG compared to PC. Conclusion: The use of VG during routine clinical conditions resulted in a modest reduction in the duration of HE (SpO₂ 2 compared to PC. The use of VG did not reduce the more severe HE.

Original language	English (US)
Pages (from-to)	129-134
Number of pages	6
Journal	Neonatology
DOIs	https://doi.org/10.1159/000444844
State	Accepted/In press - Apr 19 2016

Keywords

Arterial oxygen saturation#
Intermittent hypoxemia
Premature infant
Volume-targeted ventilation

ASJC Scopus subject areas

Developmental Biology
Pediatrics, Perinatology, and Child Health

Access to Document

10.1159/000444844

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title = "Volume Guarantee Ventilation: Effect on Preterm Infants with Frequent Hypoxemia Episodes",

abstract = "Background: Preterm infants on mechanical ventilation have spontaneous hypoxemia episodes (HE) triggered by decreases in lung volume and tidal volume (VT). Volume guarantee (VG) is a mode where the ventilator peak pressure is adjusted to keep the exhaled VT at a target level. The effect of VG on HE under routine clinical conditions has not been fully evaluated. Objective: To evaluate the effect of VG on HE in preterm infants in comparison to pressure control (PC) ventilation under routine clinical conditions. Methods: Twenty-four mechanically ventilated preterm infants with ≥4 HE of arterial oxygen saturation (SpO2) 2 2 2 2) was lower during VG compared to PC. Conclusion: The use of VG during routine clinical conditions resulted in a modest reduction in the duration of HE (SpO2 2 compared to PC. The use of VG did not reduce the more severe HE.",

keywords = "Arterial oxygen saturation#, Intermittent hypoxemia, Premature infant, Volume-targeted ventilation",

author = "Deepak Jain and Claure, {Nelson R} and Carmen D'Ugard and Jose Bello and Eduardo Bancalari",

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doi = "10.1159/000444844",

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AU - Jain, Deepak

AU - Claure, Nelson R

AU - D'Ugard, Carmen

AU - Bello, Jose

AU - Bancalari, Eduardo

PY - 2016/4/19

Y1 - 2016/4/19

N2 - Background: Preterm infants on mechanical ventilation have spontaneous hypoxemia episodes (HE) triggered by decreases in lung volume and tidal volume (VT). Volume guarantee (VG) is a mode where the ventilator peak pressure is adjusted to keep the exhaled VT at a target level. The effect of VG on HE under routine clinical conditions has not been fully evaluated. Objective: To evaluate the effect of VG on HE in preterm infants in comparison to pressure control (PC) ventilation under routine clinical conditions. Methods: Twenty-four mechanically ventilated preterm infants with ≥4 HE of arterial oxygen saturation (SpO2) 2 2 2 2) was lower during VG compared to PC. Conclusion: The use of VG during routine clinical conditions resulted in a modest reduction in the duration of HE (SpO2 2 compared to PC. The use of VG did not reduce the more severe HE.

AB - Background: Preterm infants on mechanical ventilation have spontaneous hypoxemia episodes (HE) triggered by decreases in lung volume and tidal volume (VT). Volume guarantee (VG) is a mode where the ventilator peak pressure is adjusted to keep the exhaled VT at a target level. The effect of VG on HE under routine clinical conditions has not been fully evaluated. Objective: To evaluate the effect of VG on HE in preterm infants in comparison to pressure control (PC) ventilation under routine clinical conditions. Methods: Twenty-four mechanically ventilated preterm infants with ≥4 HE of arterial oxygen saturation (SpO2) 2 2 2 2) was lower during VG compared to PC. Conclusion: The use of VG during routine clinical conditions resulted in a modest reduction in the duration of HE (SpO2 2 compared to PC. The use of VG did not reduce the more severe HE.

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KW - Intermittent hypoxemia

KW - Premature infant

KW - Volume-targeted ventilation

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