Voltage-Gated Ion Currents of Schwann Cells in Cell Culture Models of Human Neurofibromatosis

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Abstract

K+ (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor-derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalJournal of Experimental Zoology Part A: Comparative Experimental Biology
Volume300
Issue number1
StatePublished - Nov 1 2003

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Schwann cells
Neurofibromatoses
Schwann Cells
cell culture
Cell Culture Techniques
Ions
ions
Neurofibromatosis 1
Neurofibromatosis 2
Cell Proliferation
neoplasms
disease models
human diseases
cultured cells
Cultured Cells
Neoplasms
cell proliferation
cells
Growth

ASJC Scopus subject areas

  • Animal Science and Zoology

Cite this

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abstract = "K+ (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor-derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex.",
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