Vitrectomy and systemic fluconazole for treatment of endogenous fungal endophthalmitis

Nancy J. Christmas, William E. Smiddy

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


BACKGROUND AND OBJECTIVE: To investigate the efficacy of pars plana vitrectomy and oral fluconazole without injection of intravitreal antimycotic agents in the treatment of vitritis resulting from Candida endophthalmitis. PATIENTS AND METHODS: Six eyes of five patients with suspected Candida endophthalmitis were treated with pars plana vitrectomy and systemic fluconazole for at least 3 weeks. Patients were observed postoperatively for at least 4 months. RESULTS: Clinical signs of infection cleared and visual acuity improved postoperatively in all six cases. One recurrent case was attributed to a retained indwelling venous catheter. CONCLUSIONS: Treatment of advanced endogenous Candida endophthalmitis with vitrectomy and systemic fluconazole offers an effective alternative to management with intravitreal amphotericin B in selected cases.

Original languageEnglish (US)
Pages (from-to)1012-1018
Number of pages7
JournalOphthalmic Surgery and Lasers
Issue number12
StatePublished - Dec 1 1996

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Vitrectomy and systemic fluconazole for treatment of endogenous fungal endophthalmitis'. Together they form a unique fingerprint.

Cite this