Vitamins E and C: Effects on matrix components in the vascular system

Jean Marc Zingg, Mohsen Meydani, Angelo Azzi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Connective tissue in the vascular system consists of vascular smooth muscle cells (VSMC) and the interstitial extracellular matrix (ECM). VSMC are located in the media of the vascular wall surrounded by their own basement membranes and embedded within an interstitial matrix consisting mainly of type I fibrillar collagen, the glycoprotein fibronectin, tenascins, and dermatan and chondroitin sulfate proteoglycans (Raines 2000). Two major types of VSMC have been described, and their aberrant regulation is at the basis of atherosclerosis development: the contractile phenotype of VSMC is essential for hemodynamic stability and maintenance of the vascular tone, whereas the synthetic phenotype is capable of repairing the injured vessel wall by migrating, proliferating, and elaborating an appropriate ECM (reviewed in Alexander and Dzau 2000, Zingg and Azzi 2007). In addition to maintaining the vascular structure, connective tissue supports against mechanical stress generated by pulsatile blood flow, which results in hydrostatic pressure, cyclic tension, and wall shear stresses. Connective tissue cells respond to these stressors, adapt to them, and convert them into changes of the extracellular compartment (Chiquet et al. 2003).

Original languageEnglish (US)
Title of host publicationVitamin-Binding Proteins
Subtitle of host publicationFunctional Consequences
PublisherCRC Press
Number of pages30
ISBN (Electronic)9781439880203
ISBN (Print)9781439880166
StatePublished - Jan 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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