VITAMIN D3 UND SEINE ANALOGA ALS MULTIFUNKTIONELLE STEROIDHORMONE. MOLEKULARE UND KLINISCHE ASPEKTE AUS DERMATOLOGISCHER SICHT

Translated title of the contribution: Vitamin D3 and its analogues as multifunctional steroid hormones. A dermatological view of molecular and clinical aspects

M. B. Schilli, R. Paus, B. M. Czarnetzki, J. Reichrath

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Since the identification of the cholesterol derivative 1,25-dihydroxy-vitamin D3 and its analogues as potent immunomodulatory, proliferation- and differentiation-regulatory molecules, the amount of data available on the effects of these agents on the skin and its appendages has grown exponentially. This review outlines recent progress in the understanding of the molecular biology and pathophysiology of vitamin D, and new strategies for the treatment of skin diseases are discussed. Focusing on psoriasis and preliminary clinical experiences, we discuss possible therapeutic targets and perspectives for these multifunctional steroid hormones in dermatology.

Translated title of the contributionVitamin D3 and its analogues as multifunctional steroid hormones. A dermatological view of molecular and clinical aspects
Original languageGerman
Pages (from-to)445-452
Number of pages8
JournalHautarzt
Volume45
Issue number7
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Keywords

  • calcipotriol
  • calcitriol
  • gene regulation
  • immunomodulation
  • psoriasis
  • vitamin D
  • vitamin D receptor

ASJC Scopus subject areas

  • Dermatology

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