This chapter provides an understanding of the cellular machinery for the intracellular trafficking, genomic action, and metabolism of vitamin D. It focuses on two additional sets of regulatory proteins-heterogeneous ribonucleoprotein (hnRNP)-related comodulators first discovered in vitamin-D and estrogen-resistant NWPs and heat-shock protein (hsp) intracellular hormone-binding proteins that act in concert with the hnRNP comodulators. Both comodulators and cofacilitators are now known to be present and active in normal human cells. By virtue of their ability to be attracted to and interact with nucleic acid elements in both double strand (ds) and single strand (ss) format, this chapter theorizes that the hnRNP-directed events, influencing chromatin remodeling, transcription, splicing, and post-transcriptional mRNA handling, permit the same hnRNP to regulate expression of genes and gene products in serial fashion at geographically proximate sites in the cell and have termed this the "hop-scotch" model. Studies of the vitamin D resistance state in NWPs have been achieved for over 15 years with the expectation that this would provide valuable insight into how steroid hormones regulate gene expression in human primates.
|Original language||English (US)|
|Title of host publication||Vitamin D|
|Number of pages||20|
|State||Published - 2011|
ASJC Scopus subject areas