Vitamin D levels and menopause-related symptoms

Erin S. LeBlanc, Manisha Desai, Nancy Perrin, Jean Wactawski-Wende, JoAnn E. Manson, Jane A. Cauley, Yvonne L. Michael, Jean Tang, Catherine Womack, Yiqing Song, Karen C. Johnson, Mary J. O'Sullivan, Nancy Woods, Marcia L. Stefanick

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Objective: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.

Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.

Results: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's 9 0.10 for fully adjusted models).

Conclusions: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.

Original languageEnglish
Pages (from-to)1197-1203
Number of pages7
JournalMenopause
Volume21
Issue number11
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

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Keywords

  • Hot flashes
  • Menopause
  • Mood
  • Sleep
  • Vitamin D

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

LeBlanc, E. S., Desai, M., Perrin, N., Wactawski-Wende, J., Manson, J. E., Cauley, J. A., Michael, Y. L., Tang, J., Womack, C., Song, Y., Johnson, K. C., O'Sullivan, M. J., Woods, N., & Stefanick, M. L. (2014). Vitamin D levels and menopause-related symptoms. Menopause, 21(11), 1197-1203. https://doi.org/10.1097/gme.0000000000000238