Vitamin d levels and menopause-related symptoms

Erin S. LeBlanc, Manisha Desai, Nancy Perrin, Jean Wactawski-Wende, JoAnn E. Manson, Jane A. Cauley, Yvonne L. Michael, Jean Tang, Catherine Womack, Yiqing Song, Karen C. Johnson, Mary J. O'Sullivan, Nancy Woods, Marcia L. Stefanick

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women. METHODS: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses. RESULTS: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's > 0.10 for fully adjusted models). CONCLUSIONS: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.

Original languageEnglish
JournalMenopause
DOIs
StateAccepted/In press - Apr 14 2014

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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