Vitamin D from different sources is inversely associated with Parkinson disease

Liyong Wang, Marian L. Evatt, Lizmarie G. Maldonado, William R. Perry, James C. Ritchie, Gary W Beecham, Eden R Martin, Jonathan L. Haines, Margaret A Pericak-Vance, Jeffery M Vance, William K Scott

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n=478) and controls (n=431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D<20 ng/mL) and vitamin D insufficiency (total 25[OH]D<30 ng/mL) are associated with PD risk (odds ratio [OR]=2.6 [deficiency] and 2.1 [insufficiency]; P<0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (Ptrend<0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (Ptrend=0.0008 and 0.12 in individuals with 25[OH]D3<20 ng/mL and 25[OH]D3≥20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients.

Original languageEnglish
JournalMovement Disorders
DOIs
StateAccepted/In press - Jan 1 2015

Fingerprint

Vitamin D
Parkinson Disease
Sunlight
Vitamin D Deficiency
Odds Ratio
Ergocalciferols
Deficiency Diseases
Tandem Mass Spectrometry
Liquid Chromatography
Diet

Keywords

  • Diet
  • Parkinson's disease
  • Vitamin D
  • Vitamin D2

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Vitamin D from different sources is inversely associated with Parkinson disease. / Wang, Liyong; Evatt, Marian L.; Maldonado, Lizmarie G.; Perry, William R.; Ritchie, James C.; Beecham, Gary W; Martin, Eden R; Haines, Jonathan L.; Pericak-Vance, Margaret A; Vance, Jeffery M; Scott, William K.

In: Movement Disorders, 01.01.2015.

Research output: Contribution to journalArticle

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abstract = "An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n=478) and controls (n=431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D<20 ng/mL) and vitamin D insufficiency (total 25[OH]D<30 ng/mL) are associated with PD risk (odds ratio [OR]=2.6 [deficiency] and 2.1 [insufficiency]; P<0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (Ptrend<0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (Ptrend=0.0008 and 0.12 in individuals with 25[OH]D3<20 ng/mL and 25[OH]D3≥20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients.",
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AU - Beecham, Gary W

AU - Martin, Eden R

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AB - An inverse association between Parkinson disease (PD) and total vitamin D levels has been reported, but whether vitamin D from different sources, that is, 25(OH)D2 (from diet and supplements) and 25(OH)D3 (mainly from sunlight exposure), all contribute to the association is unknown. Plasma total 25(OH)D, 25(OH)D2, and 25(OH)D3 levels were measured by liquid chromatography-tandem mass spectrometry in PD patients (n=478) and controls (n=431). Total 25(OH)D was categorized by clinical insufficiency or deficiency; 25(OH)D2 and 25(OH)D3 were analyzed in quartiles. Vitamin D deficiency (total 25[OH]D<20 ng/mL) and vitamin D insufficiency (total 25[OH]D<30 ng/mL) are associated with PD risk (odds ratio [OR]=2.6 [deficiency] and 2.1 [insufficiency]; P<0.0001), adjusting for age, sex, and sampling season. Both 25(OH)D2 and 25(OH)D3 levels are inversely associated with PD (Ptrend<0.0001). The association between 25(OH)D2 and PD risk is largely confined to individuals with low 25(OH)D3 levels (Ptrend=0.0008 and 0.12 in individuals with 25[OH]D3<20 ng/mL and 25[OH]D3≥20 ng/mL, respectively). Our data confirm the association between vitamin D deficiency and PD, and for the first time demonstrate an inverse association of 25(OH)D2 with PD. Given that 25(OH)D2 concentration is independent of sunlight exposure, this new finding suggests that the inverse association between vitamin D levels and PD is not simply attributable to lack of sunlight exposure in PD patients with impaired mobility. The current study, however, cannot exclude the possibility that gastrointestinal dysfunction, a non-motor PD symptom, contributes to the lower vitamin D2 levels in PD patients.

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