Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma

May Cho, Parvin F. Peddi, Kevin Ding, Ling Chen, Denise Thomas, Jian Wang, Albert C. Lockhart, Benjamin Tan, Andrea Wang-Gillam

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Background: The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vitamin D deficiency in association with ongoing and varying degrees of malabsorption. However, little is known about the correlation between vitamin D status and prognosis in these patients.Methods: We conducted a retrospective review of vitamin D status in patients with pancreatic adenocarcinoma who were treated at Siteman Cancer Center. Patients' demographic information, clinical staging at the time of vitamin D assessment, vitamin D levels, and survival data were collected. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D (25[OH]D) level of less than 20 ng/mL, and vitamin D insufficiency was defined as a 25(OH)D level of between 20 ng/mL and 30 ng/mL.Results: Between December 2007 and June 2011, 178 patients with pancreatic adenocarcinoma had their vitamin D levels checked at the time of initial visit at this center. Of these 178 patients, 87 (49%) had vitamin D deficiency, and 44 (25%) had vitamin D insufficiency. The median 25(OH)D level was significantly lower among nonwhite patients and among patients with stage I and II disease. A 25(OH)D level of less than 20 ng/mL was found to be associated with poor prognosis (p = 0.0019) in patients with stage III and IV disease.Conclusions: Vitamin D insufficiency and deficiency were prevalent among patients with pancreatic adenocarcinoma. The vitamin D level appears to be prognostic for patients with advanced pancreatic adenocarcinoma, and its effects should be further examined in a prospective study.

Original languageEnglish (US)
Article number206
JournalJournal of translational medicine
Volume11
Issue number1
DOIs
StatePublished - Sep 8 2013

Keywords

  • Pancreatic cancer
  • Prognostic factors
  • Vitamin D
  • Vitamin D receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Cho, M., Peddi, P. F., Ding, K., Chen, L., Thomas, D., Wang, J., Lockhart, A. C., Tan, B., & Wang-Gillam, A. (2013). Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma. Journal of translational medicine, 11(1), [206]. https://doi.org/10.1186/1479-5876-11-206