Abstract
Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C®) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C®), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C®). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C® supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C®. PureWay-C® provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C® shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C® also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.
| Original language | English |
|---|---|
| Journal | Medical Science Monitor |
| Volume | 14 |
| Issue number | 11 |
| State | Published - Nov 1 2008 |
| Externally published | Yes |
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Keywords
- Absorption
- Inflammation
- Lipid metabolites
- Oxidative stress
- Serum levels
- Vitamin C
ASJC Scopus subject areas
- Medicine(all)
Cite this
Vitamin C-lipid metabolites : Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers. / Pancorbo, Dario; Vazquez, Carlos; Fletcher, Mary Ann.
In: Medical Science Monitor, Vol. 14, No. 11, 01.11.2008.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin C-lipid metabolites
T2 - Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers
AU - Pancorbo, Dario
AU - Vazquez, Carlos
AU - Fletcher, Mary Ann
PY - 2008/11/1
Y1 - 2008/11/1
N2 - Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C®) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C®), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C®). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C® supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C®. PureWay-C® provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C® shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C® also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.
AB - Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C®) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C®), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C®). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C® supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C®. PureWay-C® provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C® shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C® also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.
KW - Absorption
KW - Inflammation
KW - Lipid metabolites
KW - Oxidative stress
KW - Serum levels
KW - Vitamin C
UR - http://www.scopus.com/inward/record.url?scp=55549091088&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55549091088&partnerID=8YFLogxK
M3 - Article
C2 - 18971870
AN - SCOPUS:55549091088
VL - 14
JO - Medical Science Monitor
JF - Medical Science Monitor
SN - 1234-1010
IS - 11
ER -