Vitamin C-lipid metabolites: Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers

Dario Pancorbo, Carlos Vazquez, Mary Ann Fletcher

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C®) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C®), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C®). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C® supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C®. PureWay-C® provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C® shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C® also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.

Original languageEnglish
JournalMedical Science Monitor
Volume14
Issue number11
StatePublished - Nov 1 2008
Externally publishedYes

Fingerprint

C-Reactive Protein
Ascorbic Acid
Blood Proteins
Healthy Volunteers
Lipids
Serum
oxidized low density lipoprotein
T-Lymphocytes
Urine Specimen Collection
Oxalates
calcium ascorbate
Xenobiotics
Uric Acid
Oral Administration
Oxidative Stress
Fibroblasts
Eating
Diet

Keywords

  • Absorption
  • Inflammation
  • Lipid metabolites
  • Oxidative stress
  • Serum levels
  • Vitamin C

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Vitamin C-lipid metabolites : Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers. / Pancorbo, Dario; Vazquez, Carlos; Fletcher, Mary Ann.

In: Medical Science Monitor, Vol. 14, No. 11, 01.11.2008.

Research output: Contribution to journalArticle

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title = "Vitamin C-lipid metabolites: Uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers",
abstract = "Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C{\circledR}) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C{\circledR} serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C{\circledR}), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C{\circledR}). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C{\circledR} supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C{\circledR}. PureWay-C{\circledR} provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C{\circledR} shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C{\circledR} also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C{\circledR} is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C{\circledR}.",
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AU - Vazquez, Carlos

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N2 - Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C®) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C®), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C®). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C® supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C®. PureWay-C® provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C® shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C® also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.

AB - Background: Previously, a novel formulation of vitamin C-lipid metabolites (PureWay-C®) was shown to be more rapidly taken-up by human T-lymphocytes and more rapidly stimulate neurite outgrowth, fibroblast adhesion and inhibition of xenobiotic-induced T-cell hyperactivation. Here, PureWay-C® serum levels were measured in healthy volunteers after oral supplementation. Plasma C-reactive protein and oxidized low density lipoprotein levels (LDL) were also measured. Material/Methods: Healthy volunteers maintained a low vitamin C diet for 14 days and, following an overnight fast, received a single oral dose of (vitamin C) 1000 mg of either ascorbic acid (AA), calcium ascorbate (CaA), vitamin C-lipid metabolites (PureWay-C®), or calcium ascorbate-calcium threonate-dehydroascorbate (Ester-C®). Blood samples were collected immediately prior to the oral dose administration and at various times post ingestion. Twenty-four-hour urine collections were saved for oxalate and uric acid assays. Results: PureWay-C® supplementation leads to the highest absolute serum vitamin C levels when compared to AA, CaA and Ester-C®. PureWay-C® provides a statistically significant greater serum level than calcium ascorbate at 1, 2, 4, and 6 hours post oral supplementation whereas Ester-C® shows a less but slightly statistically significant increase at only 1 and 4 hours. Oral supplementation with PureWay-C® also led to a greater reduction in plasma C-reactive protein and oxidized LDL levels compared to the other vitamin C formulations. Conclusions: PureWay-C® is more rapidly absorbed and leads to higher serum vitamin C levels and greater reduction of plasma levels of inflammatory and oxidative stress markers than other forms of vitamin C, including Ester-C®.

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